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1. How confident are you in the management of patients with NASH in your practice?
2. Epidemiology data have shown NASH to be the fastest-growing driver of which of the following?
3. Maria, a 55-year-old Hispanic woman, presents with a BMI of 31, hypertension, and T2D diagnosed 5 years ago. Her liver function tests are normal and she has an HbA1c level of 5%, indicating her blood glucose is well under control. What is your index of suspicion for NASH?
4. Vasanti, a 65-year-old woman of south Asian descent, has a BMI of 23. Over the last 18 months, her triglycerides and ALT have been rising, and she shows a prediabetes fasting glucose level and low HDL-C level. Her family confirms she never drinks. Hepatic ultrasound showed steatosis but FIB-4 test was inconclusive. Which answer regarding further testing would be best?
5. Research into the pathophysiology of NAFLD/NASH disease progression has revealed that mortality and poor outcomes are most strongly linked with:
6. All of the emerging therapies in clinical development for NASH have enrolled patients with histologically confirmed:
7. Interim efficacy findings from the phase 3 REGENERATE trial of OCA in NASH patients with fibrosis stages F1-F3 showed: