Strategies to Provide Individualized Treatment in Moderate-to-Severe
Strategies to Provide Individualized Treatment in Moderate-to-Severe
Amy S. Paller, MS, MD, is the Chair and Walter J. Hamlin Professor in the Department of Dermatology in the Feinberg School of Medicine at Northwestern University. She is also the Director of the Northwestern University Skin Disease Research Center and a Professor of Pediatrics.
Dr. Paller is board certified in pediatrics, dermatology, and pediatric dermatology. She holds a medical degree from Stanford University School of Medicine, and a master of science degree in genetics from Brown University. Dr. Paller completed her internship and residencies in pediatrics and dermatology at Northwestern University, and her fellowship in dermatology at the University of North Carolina School of Medicine.
Dr. Paller has been a leader of several international, national, and local societies, among them as President of the Society for Investigative Dermatology (SID), the Society for Pediatric Dermatology, the International Eczema Council, and currently the International Society for Pediatric Dermatology. She has been the recipient of numerous honors, among them the Stephen Rothman Award of the SID, the Clarence Livingood Award of the American Academy of Dermatology, and the Wilma Bergfeld, MD Visioning and Leadership Award from the Women's Dermatological Society. A National Institutes of Health-funded investigator, she currently serves on the Council for the National Institute for Arthritis, Musculoskeletal and Skin Diseases. Dr. Paller serves on multiple editorial and advisory boards, and is both an editorial and grant reviewer. Dr. Paller has published almost 600 research articles, book chapters, and other contributions to the scientific literature. Her clinical and research interests include atopic dermatitis, psoriasis, genetic skin problems, diabetic ulcers, and nanotechnology approaches for topically-delivered gene therapy.
Jonathan M. Spergel, MD, PhD, is a Professor of Pediatrics, Chief of the Allergy Section, and Stuart E. Starr Endowed Chair of Pediatrics in the Perelman School of Medicine at the University of Pennsylvania. He is also the Director of the Center for Pediatric Eosinophilic Disease and the Director of the Food Allergy Research Education Center of Excellence at The Children's Hospital of Philadelphia.
Dr. Spergel is board certified in pediatrics, allergy, and immunology. He holds a medical degree and doctor of philosophy degree in biomedical sciences from Mount Sinai School of Medicine. Dr. Spergel completed his internship and residency in pediatrics at Yale-New Haven Hospital, and his fellowship in allergy and immunology at Children's Hospital in Boston.
Dr. Spergel has been named a Top Doctor by Castle Connolly and a Top Doc with National Distinction by US News and World Report for several years. He is a fellow of the American College of Allergy, Asthma, and Immunology and the American Academy of Allergy, Asthma, and Immunology, and has held multiple leadership positions with both groups. Dr. Spergel is also a fellow of the American Academy of Pediatrics and belongs to several other national and local societies. He serves on the editorial boards of multiple scientific journals, and has published over 100 peer-reviewed research publications. His clinical and research interests include asthma, atopic dermatitis, allergic rhinitis, and food allergy.
Th, T helper cell.
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Testing RecommendationsIgE, immunoglobin E.
mAb, monoclonal antibody.
Agents | Inhibitor Class | Trial Phase | Route | Patients in Trials (N) |
---|---|---|---|---|
Biologic Agents | ||||
Bermekima (MABp1) | IL-17α | 2 | SC | 1 recruiting trial (29) |
Etokimab (ANB020) | IL-33 | 2 | IV | 1 recruiting trial (300) |
GBR-830* | OX40 | 2 | SC | 1 recruiting trial (392) |
Lebrikizumab (TNX-650) | IL-13 | 2 | SC | 1 recruiting trial (275) |
MOR-106* | IL-17C | 2 | IV | 1 recruiting trial (180) |
Nemolizumab (CIM 331) | IL-31RA | 2 | SC | 1 active trial (351) |
Tralokinumab (CAT-354) | IL-13 | 3 | SC | 5 active/recruiting trials (3,348) |
Small-molecule Agents | ||||
Abrocitinib (PF-04965842) | JAK 1 | 3 | oral | 4 active/recruiting trials (4,420) |
Baricitinib (LY3009104) | JAK 1/2 | 3 | oral | 6 active/recruiting trials (3,950) |
Upadacitinib (ABT-494) | JAK 1 | 3 | oral | 4 active/recruiting trials (2,596) |
*Generic names not available upon activity launch.
IV, intravenous; JAK, Janus kinase; OX40, tumor necrosis factor receptor superfamily member 4; RA, receptor antagonist; SC, subcutaneous.
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Proven Strategies to Improve Adherence