Pediatric Atopic Dermatitis: Clinical Scenarios – Clinical Brief #3

Pathogenesis and Wrap-up


It’s estimated that 30% of the approximately 9.6 million American children with atopic dermatitis (AD) suffer from moderate to severe disease. “Suffer” is the operative word, as the disease has a wide range of deleterious effects, including unrelenting itch and sleep disturbance. When suboptimally treated, this can lead to learning disabilities and behavioral disorders resulting in long-term impact on education and psychosocial health, as well as other negative effects on both the child and the family. However, medical science is rapidly unraveling the pathogenic molecular drivers of this disease of immune dysregulation and Type 2 inflammation, and a variety of targeted treatments have recently been approved to treat children, adolescents, and even infants with moderate to severe AD.

Read more about the known impact and pathogenesis of AD in infants, children, and adolescents below:

Next, listen to what pediatric AD experts Drs. Peter Lio & Robert Sidbury have to say about the pathogenesis of pediatric AD and managing children with moderate to severe disease.