Sequencing Antibody-Drug Conjugates (ADCs) in HER2-Low Disease

Cross-trial comparison favors sequencing T-DXd first, followed by SG, in mTNBC.

Given the limitations inherent in cross-trial comparison, real-world data is needed to inform optimal sequencing. This is of particular importance as data from a small study (n=35) suggest waning efficacy with sequential therapy, with median PFS (mPFS) falling from 8.2 months with the first ADC to 3.0 months with the second (P=.004).