Evolving Treatment Landscape of EoE: Applying the Latest Evidence to Optimize Care – Clinical Brief #1

Pathophysiology of EoE


Eosinophilic esophagitis (EOE) is a chronic type 2 inflammatory disease that affects approximately 41 in 100,000 Americans and is associated with a significant clinical and psychosocial burden. EoE is characterized by accumulation of eosinophils, basophils, and mast cells in the esophagus, and when poorly controlled leads to remodeling, narrowing, and fibrosis. Early and accurate diagnosis is crucial for guiding treatment and preventing potentially irreversible esophageal damage.

Environmental interactions with the esophageal epithelium trigger an increase in interleukin-33 (IL-33) and thymic stromal lymphopoietin (TSLP) resulting in regulatory T cells (Treg) and T helper 2 cells (Th2) being activated.  This then leads to barrier disruption, tissue remodeling, and inflammation. Learn more about these factors below:

Listen to Dr. Aceves and Dr. Hirano discuss the shift in the understanding of EoE pathogenesis, and how this has helped to inform treatment.