Overcoming Disease Recurrence and Treatment Resistance in HER2-Positive Metastatic Tumors: Clinical Manifestations of HER2/3 in Gastrointestinal, Lung, and Breast Cancers

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PROVIDER STATEMENT

Provided by Integrity Continuing Education, Inc.

SUPPORTER ACKNOWLEDGEMENT

This activity is supported by independent educational grants from AstraZeneca Pharmaceuticals and Daiichi Sankyo, Inc.

PROGRAM OVERVIEW

Genomic studies have identified human epidermal growth factor receptor 2 (HER2) as the main oncogenic driving force behind some types of particularly aggressive metastatic cancers: breast cancer, gastrointestinal cancers (particularly gastric/gastroesophageal junction and colorectal), and even non-small cell lung cancer. HER2 appears to work in tandem with epidermal growth factor receptor family members, including the recently discovered HER3, in aggressive tumors with a poorer prognosis characterized frequently by treatment resistance. Fortunately, newly approved HER2-targeted treatment options work through varying mechanisms of action that may be able to obviate treatment resistance observed in older HER2-targeted pharmacologic agents. New and emerging treatments that target HER2 and HER3 may soon change standard of care for some types of HER2-driven cancers and will provide more highly personalized therapeutic options for patients with these types of metastatic cancer. This program will provide education on new and emerging treatment options for patients with HER2-altered cancers.

FACULTY

Moderator

Michael Pishvaian, MD, PhD
Associate Professor, Department of Oncology
Director of the Gastrointestinal, Developmental Therapeutics, and Clinical Research Programs
NCR Kimmel Cancer Center at Sibley Memorial Hospital
Johns Hopkins University School of Medicine
Baltimore, Maryland

 

Faculty

Minetta Liu, MD
Professor of Oncology, Mayo Clinic College of Medicine
Research Chair, Department of Oncology
Consultant, Department of Laboratory Medicine and Pathology
Medical Director, Office of Practice Specialty Collaborations and Contracts
Co-Leader, Genomics in Action Strategic Priority, Center for Individualized Medicine
Mayo Clinic
Rochester, Minnesota

 

Estelamari Rodriguez, MD
Assistant Professor of Clinical Medicine
Department of Medical Oncology
Sylvester Comprehensive Cancer Center
University of Miami
Miami, Florida

 

Benedikt Westphalen, MD
Medical Lead, Precision Oncology
Department of Hematology/Oncology
Ludwig Maximilian University of Munich
Munich, Germany

TARGET AUDIENCE

This educational activity has been designed to meet the needs of medical oncologists, pathologists, radiation oncologists, surgical oncologists, and advanced practice providers (APPs) involved in the management of patients with solid tumors.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

  • ELUCIDATE the mechanisms of action and clinical trial findings of recently approved and emerging HER2/HER3-targeted drugs for multiple tumor types
  • EXAMINE guideline recommended HER2 testing for patients with breast cancer, gastrointestinal cancers, and lung cancer

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. To receive credit, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • View the live broadcast
  • Complete the posttest evaluation form at the end of the program

A statement of credit will be issued only upon receipt of a completed activity posttest and evaluation form. Your certificate will be sent to you within four weeks of receipt of the completed evaluation.

MEDIA

Internet

ACCREDITATION

Physician Continuing Education

Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this live activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Michael Pishvaian, MD, PhD 
Consultant/Advisory Committees: AstraZeneca, Foundation Medicine, Merck
Ownership Interest: 
Perthera, Inc.
Funding to institution: 
Arcus, Merck, Seattle Genetics
Educational (Unbranded) Program Speaker: 
Novartis, Pfizer

Minetta Liu, MD
Mayo Clinic receives funding from the following commercial entities for prespecified projects and trials that I lead. I do not receive any personal compensation. No unrestricted grants are provided.
Research Support: Eisai, Exact Sciences, Genentech, Genomic Health, GRAIL, Menarini Silicon Biosystems, Merck, Novartis, Seattle Genetics, Tesaro
Advisory Boards: Adela, AstraZeneca, Celgene, Genomic Health, GRAIL, Ionis, Merck, Pfizer, Roche/Genentech, Seattle Genetics, Syndax

Estelamari Rodriguez
Consultant: AstraZeneca, Bristol Myers Squibb, Eli Lilly and Company, Genentech, Janssen Oncology
Speakers’ Bureau: Research Practice, Targeted Oncology

Benedikt Westphalen, MD
Honoraria: Amgen, Bayer, Chugai, Celgene, Falk, GlaxoSmithKline, Ipsen, Janssen, Merck, Merck Sharp & Dome Corp., Roche, Servier, SIRTeX, Taiho
Advisory Boards: Bayer, BristolMyersSquibb, Celgene, Rafael Pharmaceuticals, RedHill, Roche, Servier, Shire/Baxalta
Travel Support: Bayer, Celgene, RedHill, Roche, Servier, Taiho
Research Grants (institutional): Roche
Officer: Arbeitsgemeinschaft internistische Onkologie (AIO), Deutsche Krebshilfe (DKH), European Society of Medical Oncology (ESMO)

The Integrity Continuing Education, Inc. planners and managers have nothing to disclose.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
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For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
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DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Agenda

On the day of the program, you may access the event by going to any of the following links:

Twitter:  https://twitter.com/TumorBoardTues

Facebook: https://www.facebook.com/TumorBoardTues/

YouTube: https://www.youtube.com/channel/UC7YBDn98MBWpxHIP79JqShg

There are no fees for participating and receiving CME credit for this activity. For your participation you will be able to receive a maximum of 1.0 AMA PRA Category 1 CME CreditTM. To do so, you must participate in the virtual livestream activity and complete the posttest and evaluation following the event. A statement of credit will be issued within 4 weeks of submission of a completed activity evaluation form.