Targeting HER2: New Frontiers in Urothelial Carcinoma

Course Information
Release date: December 20, 2024
Expiration date: March 20, 2025
Estimated time to complete activity: 30 minutes
PROVIDER STATEMENT

Provided by Integrity CE, LLC.

DISCLOSURE OF COMMERCIAL SUPPORT

Supported by educational grants from Janssen Scientific Affairs, LLC and Seagen, Inc.

PROGRAM OVERVIEW

Urothelial cancer (UC) has entered the era of precision medicine, transitioning from a landscape of limited options to one with emerging targeted therapies. About 30% of patients with locally advanced or metastatic UC exhibit potentially targetable HER2 expression. In this immersive, case-driven activity, expert faculty delve into cutting-edge therapeutic strategies, emerging molecular classifications, and innovative antibody-drug conjugates (ADCs) targeting HER2. Follow a patient’s journey through targeted therapies such as disitamab vedotin and trastuzumab deruxtecan, while examining the latest clinical trial data for novel agents and combinations poised to expand the HER2 therapeutic armamentarium. Although HER2-targeting ADCs show promising efficacy, they also present unique toxicity challenges, including peripheral neuropathy and interstitial lung disease/pneumonitis. Dr. Galsky and Dr. Miller navigate these issues by integrating safety measures aligned with current evidence, best practices, and guideline recommendations, offering a comprehensive look at real-world clinical decision-making in UC treatment.

Learning Objectives
TARGET AUDIENCE

This educational activity has been designed to meet the needs of medical and surgical oncologists, urologists, physician assistants, nurse practitioners, nurses, and other healthcare providers involved in treatment and management of patients with genitourinary cancer.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

  • Select personalized treatments for patients with genitourinary malignancies based on disease and patient characteristics
  • Integrate strategies to mitigate and manage toxicities associated with novel therapies and emerging combination regimens
Faculty Information and Disclosures
FACULTY
Matt Galsky, MD
Professor of Medicine
Department of Tisch Cancer Institute
Icahn School of Medicine at Mount Sinai
New York, New York
Eric Miller, MD
Clinical Fellow
Hematology and Medical Oncology
Icahn School of Medicine at Mount Sinai
New York, New York
DISCLOSURE OF CONFLICTS OF INTEREST

Integrity CE, LLC requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity CE, LLC for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Matt Galsky, MD
Advisory Boards: AbbVie, Alligator, Analog Devices, Asieris, AstraZeneca, Basilea, Bicycle, Bristol Myers Squibb, Curis, Dragonfly, EMD Serono, Fujifilm, Genentech, Gilead, GlaxoSmithKline, Janssen, Merck, Numab, Pfizer, Rappta Therapeutics, Seagen, Silverback, UroGen, Veracyte
Research: AstraZeneca, Bristol Myers Squibb, Dendreon, Genentech, Merck, Novartis

Eric Miller, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

The Integrity CE, LLC planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

Accreditation Information
DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of December 20, 2024 through March 20, 2025, participants must:

  • Read the learning objectives
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 50% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity CE, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity CE, LLC designates this enduring material for a maximum of 0.5 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity CE, LLC at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity CE, LLC does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimers and Technical Requirements
MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity CE, LLC, you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
  • Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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