Optimizing Germline Mutation Testing in Breast Cancer – Clinical Brief #2

Course Information
Release date: February 5, 2025
Expiration date: May 5, 2025
Estimated time to complete activity: 15 minutes
PROVIDER STATEMENT

This activity is provided by Integrity CE, LLC.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by educational grants from AstraZeneca Pharmaceuticals and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

Pathogenic germline BRCA mutations profoundly influence breast cancer risk, with carriers facing lifetime penetrance exceeding 60% and heightened vulnerability to subsequent malignancies. Genetic testing is crucial for informing prophylactic measures, surgical decisions, and therapeutic strategies, yet remains severely underutilized. This expert-led, evidence-based social media series provides surgeons and advanced practice providers with essential skills to identify testing candidates, provide comprehensive patient counseling, and offer personalized therapy – ultimately improving outcomes for patients with hereditary breast cancer predisposition. This clinical brief focuses on optimizing surgical and therapeutic care.

Learning Objective
TARGET AUDIENCE

This educational activity was designed for breast and general surgeons and surgical advanced practice professionals who treat and manage patients with breast cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

  • Apply germline mutation testing based on recently updated guidelines to identify patients at high risk of developing breast cancer and personalize preventive and treatment decisions
Faculty Information and Disclosures
FACULTY CHAIR
Eleftherios Mamounas, MD, MPH, FACS
Medical Director, Breast Program and Research Activities
AdventHealth Cancer Institute
Professor of Surgery
University of Central Florida
Clinical Professor of Clinical Sciences
Florida State University College of Medicine
Tallahassee, Florida
FACULTY DISCUSSANTS
Stephanie L. Graff, MD, FACP, FASCO
Director, Breast Oncology
Lifespan Cancer Institute
Co-Lead, Breast Cancer Translational Disease Research Group
Legorreta Cancer Center at Brown University
Associate Professor of Medicine
Warren Alpert Medical School of Brown University
Providence, Rhode Island
Kelly K. Hunt, MD, FACS, FSSO
Olla Stribling Distinguished Chair for Cancer Research
Chair, Department of Breast Surgical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas
DISCLOSURE OF CONFLICTS OF INTEREST

Integrity CE, LLC requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity CE, LLC for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Stephanie Graff, MD, FACP, FASCO
Consultant: AstraZeneca, Daiichi Sankyo, Genentech, Gilead Sciences, Lilly, Novartis, Pfizer, SeaGen, Stemline/Menarini
Research Funding: AstraZeneca, Daiichi Sankyo, Lilly, Novartis
Stock: HCA Healthcare

Kelly K. Hunt, MD, FACS, FSSO
Advisory Board: ArmadaHealth
Editor-in-Chief Current Breast Cancer Reports: Springer Nature
Honorarium: AstraZeneca
Research Funding: Cairn Surgical, Lumicell

Eleftherios Mamounas, MD, MPH, FACS
Consultant: Biotheranostics, Delphi Diagnostics, Exact Sciences, GE Healthcare, Merck, Novartis, Provapharm
Speaker: Exact Sciences, Merck, Novartis
Stock Ownership: Moderna

The Integrity CE, LLC planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

Accreditation Information
DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of February 5, 2025 through May 5, 2025, participants must:

  • Read the learning objectives
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity CE, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity CE, LLC designates this enduring material for a maximum of 0.25 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity CE, LLC at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity CE, LLC does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimers and Technical Requirements
MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity CE, LLC, you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
  • Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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