Emerging Strategies for Improving Outcomes in Patients With Inflammatory Airway Disease: Understanding the Role of IL-33

Course Information
Release date: December 9, 2024
Expiration date: December 9, 2025
Estimated time to complete activity: 60 minutes
PROVIDER STATEMENT

This activity is provided by Integrity CE, LLC.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from AstraZeneca Pharmaceuticals.

PROGRAM OVERVIEW

Despite a broad range of available treatments, many patients with inflammatory airway diseases experience frequent respiratory symptoms and remain vulnerable to poor outcomes, indicating an unmet need for additional management options. A potential strategy that has recently emerged is the use of therapies that target the alarmin interleukin (IL)-33. IL-33 is a nuclear cytokine that plays a crucial role in the activation of a broad range of immune cells and the release of pro-inflammatory cytokines and chemokines in response to infection or environmental insult. Based on these observations, IL-33 is being investigated for the treatment of persistent exacerbation of respiratory symptoms in patients with conditions such as chronic obstructive pulmonary disease (COPD), acute viral respiratory infections, and other related respiratory conditions. Join our esteemed clinician faculty for a review of the role of IL-33 in the pathophysiology of these diseases, along with a discussion of current evidence regarding the efficacy and safety of emerging anti-IL-33 therapies and an exploration of their therapeutic potential.

Learning Objectives
TARGET AUDIENCE

This educational activity has been designed for pulmonologists and other clinicians involved in the management of patients with acute respiratory infections.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

  • Describe the role of IL-33 in the pathophysiology of COPD, acute viral respiratory infections, and other respiratory conditions
  • Summarize current clinical trial data on the efficacy and safety of anti-IL-33/ST2 therapies for the treatment of COPD, acute viral respiratory infections, and other respiratory conditions
  • Utilize current clinical trial evidence to identify patients who may be suitable candidates for treatment with anti-IL-33/ST2 therapies if and when they become available
Faculty Information and Disclosures

FACULTY

Gerard J. Criner, MD, FACP, FACCP
Chair and Professor
Thoracic Medicine and Surgery
Lewis Katz School of Medicine
Director, Temple Lung Center
Temple University
Philadelphia, Pennsylvania
Nicola A. Hanania, MD, MS, FCCP, FACP, FRCP(C), FERS
Professor of Medicine, Section of Pulmonary and Critical Care Medicine
Director, Airways Clinical Research Center
Baylor College of Medicine
Chief, Section of Pulmonary and Critical Care Medicine
Ben Taub Hospital
Houston, Texas

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity CE, LLC requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity CE, LLC for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Gerard J. Criner, MD, FACP, FACCP 
Consultant: Apreo, AstraZeneca, Boehringer Ingelheim, GSK, Olympus, Pulmonx, Sanofi/Regeneron

Nicola A. Hanania, MD, MS, FCCP, FACP, FRCP(C), FERS
Advisor/Consultant: AstraZeneca, Boehringer Ingelheim, Genentech, GSK, Sanofi/Regeneron
Research Grant Support (to institution): American Lung Association, AstraZeneca, Genentech, GSK, National Heart, Lung, & Blood Institute, Sanofi

The Integrity CE, LLC planners and managers do not have any relevant financial relationships or relationships to products or devices with ineligible companies.

Accreditation Information
DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of December 9, 2024 through December 9, 2025, participants must:

  • Read the learning objectives
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 60% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity CE, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity CE, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity CE, LLC at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity CE, LLC does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimers and Technical Requirements
MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity CE, LLC, you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
  • Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Continue to Pretest