Community Counts: Exploring Transcription Regulation & Immunotherapy for ES-SCLC: Tweetorial #3




Provided by Integrity Continuing Education, Inc.


Supported by an educational grant from Jazz Pharmaceuticals, Inc.


Accounting for only 13% of all lung cancer cases, small cell lung cancer (SCLC) is pathologically and molecularly distinct from non-small cell lung cancer and is far more aggressive. Most patients (~75%) are diagnosed with metastatic disease and although SCLC initially responds well to 1st-line chemotherapy, relapse within 2 to 4 months is common. There are currently only 2 approved treatments for SCLC after relapse – one of which was approved in 2020 and is largely unfamiliar to clinicians. This new agent, lurbinectedin, operates on a completely different mechanism of action by inhibiting oncogenic transcription. A few immune checkpoint inhibitors (ICIs) have also been approved for SCLC in the 1st- and 3rd-lines of treatment. This activity will familiarize clinicians with how these entities work to improve outcomes in SCLC.


Narjust Duma, MD
Associate Director of Cancer Care Equity
Thoracic Oncologist
Lowe Center for Thoracic Oncology
Dana-Farber Cancer Institute
Member of the Faculty
Harvard Medical School
Boston, Massachusetts


Thomas W. LeBlanc, MD
Associate Professor of Medicine
Associate Professor of Population Health Sciences
Duke Cancer Institute
Durham, North Carolina


Release date: January 26, 2022
Expiration date: January 26, 2023
Estimated time to complete activity: 30 minutes



This educational activity has been designed to meet the needs of oncologists, pathologists, histologists, pulmonologists, and fellows in the aforementioned specialties.


Upon completion of this educational activity, participants should be able to:

  • Compare efficacy and safety data for new and emerging treatments for second-line extensive-stage-SCLC (ES-SCLC), as well as for immunotherapies approved in subsequent lines
  • Identify strategies for best supportive care to enhance quality of life in patients with relapsed or refractory ES-SCLC

There are no fees for participating and receiving CME credit for this activity. During the period of January 26, 2022 through January 26, 2023 participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 100%.




Physician Continuing Education


Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


Integrity Continuing Education, Inc. designates this other activity for a maximum of 0.5 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or


Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Narjust Duma, MD
Consulting Fees (eg. advisory boards): AstraZeneca, BI Oncology, Bristol-Myers Squibb, Janssen, Pfizer
Speakers’ Bureaus: Neogenomics

 Thomas W. LeBlanc, MD
Consulting Fees: AbbVie, Amgen, Astellas, AstraZeneca, BlueNote, Bristol-Myers Squibb/Celgene, CareVive, FlatIron, Genentech, GlaxoSmithKline, Jazz Pharmaceuticals, Pfizer, Seattle Genetics
Royalty: UpToDate
Speakers’ Bureaus: AbbVie, Aglos, Bristol-Myers Squibb/Celgene

The Integrity Continuing Education, Inc. planners and managers have nothing to disclose.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)


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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Continue to Pretest