Challenging Cases in CKD Anemia: The Kidneys and Heart as Linked Parts – Clinical Brief #3

Emerging Therapies for Anemia in CKD: Focus on HIF-PHIs

Please watch the video below, then read the supporting information that follows and advance to the posttest by clicking the Continue to posttest button.

A current shortcoming in chronic kidney disease (CKD)-related anemia treatment is that intravenous iron and erythropoiesis-stimulating agents (ESAs) are usually not given despite high prevalence, incidence, and persistence of the disease.

Barriers to providing these treatments include:

Hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHIs) are an emerging oral therapy class that stimulate endogenous erythropoietin (EPO) production.

Randomized clinical trial findings to date include:

CV safety findings vs ESAs: