Course Information

Release date: April 15, 2025
Expiration date: April 15, 2026
Estimated time to complete activity: 45 minutes

PROVIDER STATEMENT

This activity is provided by Integrity CE, LLC.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by educational grants from AstraZeneca Pharmaceuticals and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

Pathogenic germline BRCA mutations profoundly influence breast cancer risk, with carriers facing lifetime penetrance exceeding 60% and heightened vulnerability to subsequent malignancies. Genetic testing is crucial for informing prophylactic measures, surgical decisions, and therapeutic strategies, yet remains severely underutilized. This expert-led, evidence-based activity provides surgeons and advanced practice providers with essential skills to identify testing candidates, provide comprehensive patient counseling, and offer personalized therapy – ultimately improving outcomes for patients with hereditary breast cancer predisposition. Join Drs. Hunt, Mamounas, and Robson to hear their insights on integrating updated testing guidelines into practice, optimizing surgical and therapeutic care, and emerging strategies and clinical trials.

Learning Objectives

TARGET AUDIENCE

This educational activity has been designed to meet the needs of breast and general surgeons and surgical advanced practice professionals who treat and manage patients with breast cancer.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

Apply germline mutation testing based on recently updated guidelines to identify patients at high risk of developing breast cancer and personalize preventive and treatment decisions
Integrate alternative models in the delivery of germline testing with focus on integrating surgeons and oncology advanced practitioners in the delivery of germline testing and pre- and post- patient counseling

Faculty Information and Disclosures

FACULTY

	Kelly K. Hunt, MD, FACS, FSSO Olla Stribling Distinguished Chair for Cancer Research Chair, Department of Breast Surgical Oncology The University of Texas MD Anderson Cancer Center Houston, Texas
	Eleftherios Mamounas, MD, MPH, FACS Medical Director, Breast Program and Research Activities AdventHealth Cancer Institute Professor of Surgery University of Central Florida Clinical Professor of Clinical Sciences Florida State University College of Medicine Tallahassee, Florida
	Mark Robson, MD Chief, Breast Medicine Service Attending Physician Breast Medicine and Clinical Genetics Services Department of Medicine Memorial Sloan Kettering Cancer Center Professor of Medicine Weill Cornell Medical College New York, New York

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity CE, LLC requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity CE, LLC for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated. The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Kelly K. Hunt, MD, FACS, FSSO
Advisory Board: ArmadaHealth
Editor-in-Chief Current Breast Cancer Reports: Springer Nature
Honorarium: AstraZenecaResearch Funding: Cairn Surgical, Lumicell

Eleftherios Mamounas, MD, MPH, FACS
Consultant: Biotheranostics, Delphi Diagnostics, Exact Sciences, GE Healthcare, Merck, Novartis, Provapharm
Speaker: Exact Sciences, Merck, Novartis
Stock Ownership: Moderna

Mark Robson, MD
Advisory Boards: Artios Pharma, AstraZeneca, Change Healthcare, Daiichi Sankyo, Epic Sciences, GlaxoSmithKline, Merck, Pfizer, Tempus Lab, Zenith Pharma
Consultant: Artios Pharma, AstraZeneca, Change Healthcare, Daiichi Sankyo, Epic Sciences, GlaxoSmithKline, Merck, Pfizer, Tempus Lab, Zenith Pharma
Research Funding: AstraZeneca, Merck, Pfizer

The Integrity CE, LLC planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

Accreditation Information

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of April 15, 2025 through April 15, 2026, participants must:

Read the learning objectives
Complete the pretest
Study the educational activity
Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 60% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity CE, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity CE, LLC designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity CE, LLC at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity CE, LLC does not recommend the use of any agent outside of the labeled indications. The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimers and Technical Requirements

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity CE, LLC, you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent) Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS Plug-in: Adobe^® Flash^® Player 10

Adobe^® Flash^® Player 10 plug-in should be downloaded
Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below: Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: April 15, 2025Expiration date: April 15, 2026Estimated time to complete activity: 45 minutes

Optimizing Germline Mutation Testing in Breast Cancer – An In the Clinic Curriculum