Ankylosing spondylitis (AS) affects up to 1.4% of Americans and is a chronic and severe type of spondyloarthritis (SpA) that primarily affects the axial skeleton, with symptoms of chronic back pain, stiffness, and progressive loss of spinal mobility. The diagnosis of AS may be delayed by up to 14 years, and if not adequately treated, AS can lead to substantial disability, including total fusion of the axial skeleton, and impaired quality of life. Tumor necrosis factor inhibitors (TNFis) were the first biologic agents approved for AS, but in some patients, the efficacy of TNFi therapy can wane over time, whereas others are unable to tolerate these medications. In 2016, secukinumab gained FDA approval as the first IL-17A inhibitor for AS, and in 2019, ixekizumab, another IL-17A inhibitor, received approval for AS. In addition, new clinical practice guidelines were published in October 2019, providing updated guidance on the evidence-based management of AS, including the roles of secukinumab and ixekizumab. Healthcare providers must be knowledgeable of the underlying disease, diagnostic approaches, guideline recommendations, current therapies, and when to refer to a rheumatologist in order to truly optimize outcomes for patients with AS.
Marina N. Magrey, MD
Professor of Medicine
Case Western Reserve University
This educational activity has been designed to meet the needs of family medicine practitioners, including primary care physicians, nurse practitioners, physician assistants, and other healthcare professionals involved in the management of patients with ankylosing spondylitis.
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A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.
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Marina N Magrey, MD
Consulting Fees: AbbVie, Eli Lilly, Novartis, Pfizer, UCB
Contracted Research: AbbVie, UCB
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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.
Provided by Integrity Continuing Education, Inc.
Supported by an educational grant from Novartis Pharmaceuticals Corporation.
Please note that the livestream will start at 6:00 PM Eastern Time.
Topics to be discussed:
6:45 PM: Question and Answer Session
7:00 PM: Event ends
Please use the link below to access the live webcast the day of the event.