Optimizing Patient Outcomes in Bipolar Disorder: Long-term Management of Major Depressive Episodes.

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Wednesday, July 21, 2021
7:00 PM – 8:00 PM ET/ 4:00 PM – 5:00 PM PT



Bipolar disorder is a complex illness, and its diagnosis and management remain among the most challenging facets of clinical psychiatry. Patients with bipolar disorder are most likely to present with depression and are often misdiagnosed with unipolar depression. Many patients wait years for a correct diagnosis. Distinguishing between unipolar and bipolar depression (BPD) is often difficult, and the frequent occurrence of mixed features can make the differential diagnosis challenging. Medical and psychiatric comorbidities are also common in patients with bipolar depression and complicate the diagnosis and treatment. Persons with bipolar disorder have a high incidence of metabolic syndrome and other cardiovascular risk factors, while obesity and inactivity are associated with more severe illness and poorer treatment outcomes.  Anxiety disorders and substance use disorder are among the most common psychiatric comorbidities in patients with bipolar disorder. Accurate diagnosis and consideration of comorbidities can prevent inappropriate or ineffective pharmacotherapy. This activity will provide insights to enhance healthcare providers’ knowledge of the accurate diagnosis and pharmacotherapeutic treatment of bipolar disorder. An expert faculty will discuss practical patient-centered strategies for diagnosis and management of bipolar depression, considerations for medical and psychiatric comorbidities, and evidence-based treatment strategies for bipolar depression.


Leslie Citrome, MD, MPH
Clinical Professor
Psychiatry & Behavioral Sciences
New York Medical College
Valhalla, New York


Trisha Suppes, MD, PhD
Professor of Medicine
Department of Psychiatry & Behavioral Sciences
Stanford University School of Medicine
Director, Exploratory Therapeutics Laboratory
Treasurer Elect American Society of Clinical Psychopharmacology
Immediate Past President International Society for Bipolar Disorders
Founder, VA Palo Alto Bipolar and Depression Research Program
Director, VA Palo Alto CSP NODES
VA Palo Alto Health Care System
Palo Alto, California


This educational initiative is designed for psychiatrists, psychiatric nurse practitioners and physician assistants working with patients with bipolar disorder.


  • Formulate a differential diagnosis of BD, differentiating BPD from unipolar depression, MDD, subsyndromal mania/hypomania, and other disorders
  • Propose appropriate and effective treatment for major depressive episodes associated with BD
  • Integrate strategies for treatment of patients with BPD and comorbidities
  • Apply management and patient education recommendations in current clinical practice guidelines to routine care of patients with BD


There are no fees for participating and receiving CME credit for this activity.

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.




Physician Continuing Education


Accreditation Statement
Integrity Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


Integrity Continuing Education designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


For information about ACCME accreditation of this activity, please contact Integrity Continuing Education at (855) 835-4004 or cme@integrityce.com.


Integrity Continuing Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The following faculty/planners reported the financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of these CME activities:

Leslie Citrome, MD, MPH
Royalty: Wiley (Editor-in-Chief, International Journal of Clinical Practice, through end 2019), UpToDate (reviewer), Springer Healthcare (book), Elsevier (Topic Editor, Psychiatry, Clinical Therapeutics
Consulting Fees (eg. advisory boards): AbbVie, Acadia, Alkermes, Allergan, Angelini, Astellas, Avanir, Axsome, BioXcel, Boehringer Ingelheim, Cadent Therapeutics, Eisai, Impel, Intra-Cellular Therapies, Janssen, Karuna, Lundbeck, Luye, Lyndra, Medavante-ProPhase, Merck, Neurocrine, Noven, Osmotica, Otsuka, Relmada, Sage, Shire, Sunovion Pharmaceuticals, Inc., Takeda, Teva, University of Arizona, and one-off ad hoc consulting for individuals/entities conducting marketing, commercial, or scientific scoping research
Fees for Non-CME/CE Services Received Directly from a Commercial Interest or their Agents (eg. speakers’ bureaus): AbbVie, Acadia, Alkermes, Allergan, Angelini, Eisai, Intra-Cellular Therapies, Janssen, Lundbeck, Merck, Neurocrine, Noven, Otsuka, Sage, Shire, Sunovion Pharmeuticals, Inc., Takeda, Teva
Ownership Interest: Stocks (small number of shares of common stock): Bristol Myers Squibb, Eli Lilly, Johnson & Johnson, Merck, Pfizer (purchased > 10 years ago)

Trisha Suppes, MD, PhD
Research grants: Merck, National Institute on Drug Abuse, National Institute of Health, VA
Cooperative Studies Program: VA OR&D, Palo Alto Health Sciences, Stanley Medical Research Institute, and Pathways Genomics
Consulting fees: Allergan, Inc., Intra-Cellular Therapies, Sunovion Pharmaceuticals, Inc., and Impel NeuroPharma Inc.
Honoraria: CME Institute (Physicians Postgraduate Press, Inc.) and CMEology
Royalties: American Psychiatric Association Publishing, Hogrefe Publishing, Jones and Bartlett, and Wolters Kluwer Health (UpToDate)
Travel reimbursement: Sunovion Pharmaceuticals, Inc.

The Integrity Continuing Education, Inc planners and managers have nothing to disclose.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc, you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)


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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.


Provided by Integrity Continuing Education, Inc.


Supported by an educational grant from Sunovion Pharmaceuticals, Inc.



On the day of the program, you may access the event by any of the following links:

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YouTube: https://www.youtube.com/channel/UC7YBDn98MBWpxHIP79JqShg

There are no fees for participating and receiving CME credit for this activity. For your participation you will be able to receive a maximum of 1.0AMA PRA Category 1 CME credit™. To do so, you must participate in the virtual livestream activity and complete the posttest and evaluation following the event. A statement of credit will be issued only upon submission of a completed activity evaluation form.