Getting Under the Skin With GPP: Understanding and Treating a Life-Threatening Dermatologic Disorder – Thursday, September 28, 2023

Join us for a live interactive CME webcast!

Thursday, September 28, 2023
7:30 PM – 8:30 PM EDT

Course Information

This educational activity is provided by Integrity Continuing Education, Inc.
Presented in partnership with the Miami Society of Dermatology and Cutaneous Surgery.


This activity is supported by an independent medical educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.


Characterized by severe flares of painful, pruritic, pus-filled blisters, generalized pustular psoriasis (GPP) is a rare dermatologic disorder that many dermatologists have never seen—at least not that they realized. Historically thought of as a severe form of plaque psoriasis (PsO), recent insights into the pathogenesis of GPP show it to be a distinct immuno-inflammatory disease driven by overactivity of the
IL-36 pathway.

Join GPP expert Dr. Mark Lebwohl to find out what dermatologists and other healthcare professionals need to know about the pathogenesis of GPP, the mechanism of action of IL-36 receptor antagonists, and how to recognize, diagnose, and manage patients with this inflammatory cutaneous disease.

Learning Objective

This educational program is designed for dermatologists as well as nurse practitioners and physician assistants who could be involved in recognizing and managing rare dermatologic conditions including GPP.


Upon completion of this educational activity, participants should be able to:

  • Identify patient characteristics, common comorbidities, and frequently observed triggers that should raise the index of suspicion for GPP and lead to a timelier diagnosis
  • Describe the pathogenesis of GPP and the mechanism of action of IL-36 receptor antagonists
  • Incorporate new and emerging IL-36 receptor inhibitors to treat and prevent GPP flares based on recent clinical trial findings
  • Develop a multidisciplinary, patient-centric strategy to address the cutaneous and extracutaneous disease burden of GPP
Faculty Information and Disclosures
Mark G. Lebwohl, MD
Dean for Clinical Therapeutics
Icahn School of Medicine at Mount Sinai
Professor and Chairman Emeritus
Kimberly and Eric J. Waldman Department of Dermatology
New York, New York

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Mark G. Lebwohl, MD
Research funds: AbbVie, Amgen, Arcutis Biotherapeutics, Inc., Avotres, Boehringer Ingelheim; Cara Therapeutics, Dermavant Sciences, Eli Lilly, Incyte, Inozyme, Janssen Research & Development, LLC, Ortho Dermatologics, Pfizer, Sanofi-Regeneron, UCB
Consulting fees: Almirall, AltruBio, Inc., AnaptysBio, Arcutis Biotherapeutics, Inc., AstraZeneca, Avotres Therapeutics, Brickell Biotech, Boehringer Ingelheim, Bristol Myers Squibb, Castle Biosciences, Celltrion, Corevitas, Dermavant Sciences, EPI Health, Evommune, Inc., Facilitation of International Dermatology Education, Forte Biosciences, Foundation for Research and Education in Dermatology, Galderma, Genentech, Incyte, LEO Pharma, Meiji Seika Pharma, Mindera, Pfizer, Seanergy, Strata, Trevi, Verrica

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

Accreditation Information

There are no fees for participating and receiving CME credit for this activity. To receive credit, participants must:

  • Complete the pretest
  • View the live webcast
  • Complete the posttest and evaluation form at the end of the program

A statement of credit will be issued only upon receipt of a completed activity evaluation form. Certificates will be sent via email within four weeks of receipt of the competed evaluation form.


Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


Integrity Continuing Education, Inc. designates this live activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimers and Technical Requirements

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)


Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
  • Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements


The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.


On the day of the webcast, you can access the event at this link:

There are no fees for participating and receiving CME credit for this activity. For your participation, you will be able to receive a maximum of 1.0 AMA PRA Category 1 CME Credit™. To do so, you must participate in the webcast and complete the posttest and evaluation following the event. A statement of credit will be issued via email within four weeks of submission of a completed activity evaluation form.