Utilizing Real World Evidence: Focus on Multiple Myeloma in Older Adults




This CME activity for ACCME credit is provided by Integrity Continuing Education, Inc.

This CE activity for ANCC credit is jointly provided by Global Education Group and Integrity Continuing Education, Inc.


Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc.


Evidence has demonstrated that undertreatment of fit elderly multiple myeloma (MM) patients occurs more frequently than overtreatment. While overtreatment of frail MM patients can induce unnecessary morbidity and mortality, an appropriate assessment for frailty is key to determine whether the patient is actually frail or in fact fit. This step ensures optimal outcomes and improved health-related quality of life.

This In The Clinic activity features a discussion on proper assessment of older MM patients, different scoring systems, the role of real world evidence (RWE), and trials that support the use of RWE. The clinical case scenarios will allow participants to utilize information from the discussions. A simplified, downloadable frailty scoring tool is also included.


Rafael Fonseca, MD (Moderator)
Chief Innovation Officer
Getz Family Professor of Cancer
Department of Hematology/Oncology
Distinguished Mayo Clinic Investigator
Phoenix, Arizona


Faith Davies, MBBCh, MRCP, MD, FRCPath
Professor of Medicine
Director, Myeloma Clinical Program
Perlmutter Cancer Center
NYU Langone Health
New York, New York


Robert Orlowski, MD, PhD
Florence Maude Thomas Cancer Research Professor
Professor, Department of Experimental Therapeutics
Director, Myeloma Section
The University of Texas
MD Anderson Cancer Center
Houston, Texas


Hira Mian, MD
Hematology Oncologist
Juravinski Cancer Centre
Assistant Professor of Oncology
McMaster University
Ontario, Canada


Release date: February 28, 2022
Expiration date: February 28, 2023
Estimated time to complete activity: 60 minutes



This educational activity has been designed to meet the needs of hematologist/oncologists, medical oncologists, physician assistants, nurse practitioners, and advanced practice nurses who treat and manage patients with MM.


Upon completion of this educational activity, participants should be able to:

  • ASSESS patients for fitness/frailty to select appropriate treatment based on individual results
  • EVALUATE patient data, including real-world data such as patient reported outcomes and assessment scores, to determine the most appropriate treatment regimens
  • IDENTIFY strategies for managing toxicities and comorbidities associated with MM in older patients

There are no fees for participating and receiving CE/CME credit for this activity. During the period of February 28, 2022 through February 28, 2023, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.




Physician Continuing Education

Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
Integrity Continuing Education, Inc. designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Education
Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This educational activity for 1.0 contact hour is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.


For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about ANCC accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.


Integrity Continuing Education, Inc. and Global Education Group require instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Faith Davies, MBBCh, MRCP, MD, FRCPath
Consultant: AbbVie, Amgen, Bristol Myers Squibb/Celgene, GlaxoSmithKline, Janssen, Oncopeptide, Sanofi, Takeda

Rafael Fonseca, MD
Consultant: AbbVie, Aduro, Amgen, Bayer, Bristol Myers Squibb, Celgene, GlaxoSmithKline, Janssen, Juno, Kite, Merck, Novartis, OncoTracker, Pharmacyclics, Sanofi, Takeda
Scientific Advisory Boards: Adaptive Biotechnologies, OncoTracker

Hira Miran, MD
Research Funding: Janssen
Advisor/Speaker: Amgen, Bristol Myers Squibb, GlaxoSmithKline, Janssen, Sanofi, Takeda

Robert Orlowski, MD, PhD
Consultant: AbbVie, Bristol Myers Squibb, GlaxoSmithKline Biologicals, Karyopharm Therapeutics, Inc., Meridian Therapeutics, Monte Rosa Therapeutics, Neoleukin Corporation, Oncopeptides AB, Regeneron Pharmaceuticals, Inc.

The following project managers/planners: Lindsay Borvansky, Ashley Cann, Samuel Ciociola, Donna Fausak, Andrea Funk, Liddy Knight, David Lemler, PhD, and Rhys Williams, RN, MSN, FNP, reported that they or their spouses/life partners, have no financial relationships or relationships to products or devices with commercial interests related to the content of this CE activity.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. and Global Education Group do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)


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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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