Utilizing Real World Evidence: Focus on Multiple Myeloma in Older Adults – Tweetorial #2




Provided by Integrity Continuing Education, Inc. 


Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc.


Evidence has demonstrated that undertreatment of fit elderly multiple myeloma (MM) patients occurs more frequently than overtreatment. While overtreatment of frail MM patients can induce unnecessary morbidity and mortality, an appropriate assessment for frailty is key to determine whether the patient is actually frail or in fact fit. This step ensures optimal outcomes and improved health-related quality of life.

This activity will focus on proper assessment of older patients, different scoring systems, the role of real-world evidence (RWE), and trials that support the use of RWE.  A link to a simplified, downloadable frailty scoring tool will also be provided.


Irene Ghobrial, MD
Professor of Medicine
Medical Oncology
Harvard University
Senior Physician, Department of Medical Oncology
Dana-Farber Cancer Institute
Boston, Massachusetts


Robert Z. Orlowski, MD, PhD
Florence Maude Thomas Cancer Research Professor
Professor, Department of Experimental Therapeutics
Director, Myeloma Section
The University of Texas
MD Anderson Cancer Center
Houston, Texas


Release date: April 7, 2022
Expiration date: April 7, 2023
Estimated time to complete activity: 15 minutes



This educational activity has been designed to meet the needs of community-based hematologist/oncologists, medical oncologists, physician assistants, and nurse practitioners who treat patients with MM.


Upon completion of this educational activity, participants should be able to:

  • ASSESS patients for fitness/frailty to select appropriate treatment based on individual results
  • EVALUATE patient data, including real-world data such as patient reported outcomes and assessment scores, to determine the most appropriate treatment regimens

There are no fees for participating and receiving CME credit for this activity. During the period of April 7, 2022 through April 7, 2023, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 100%.




Physician Continuing Education

Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


Integrity Continuing Education, Inc. designates this other activity for a maximum of 0.25 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.


Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Irene Ghobrial, MD
Consultant: Amgen, Celectar, Menarini Silicon Biosystems, The Binding Site
Consultant/Advisory Board: Janssen, Pfizer, Sanofi,
Consultant/Speaker: 10x Geonomics, Bristol-Myers Squibb, Celgene, GlaxoSmithKline, Janssen
Speaker: AbbVie, Novartis, Vor Biopharma
Spouse: Chief Medical Officer, Disc Medicine

Robert Z. Orlowski, MD, PhD
Consultant: AbbVie, Bristol Myers Squibb, GlaxoSmithKline Biologicals, Karyopharm Therapeutics, Inc., Meridian Therapeutics, Monte Rosa Therapeutics, Neoleukin Corporation, Oncopeptides AB, Regeneron Pharmaceuticals, Inc.

The Integrity Continuing Education, Inc. planners and managers have nothing to disclose.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)


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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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