Unlocking Epigenetic Secrets from the Uterus: Therapeutic Options for Advanced and Recurrent Endometrial Cancer – Tweetorial #2




This CME activity is provided by Integrity Continuing Education, Inc.


Supported by independent educational grants from Eisai, GlaxoSmithKline, and Merck Sharp & Dohme Corp.


Endometrial cancer (EC) is the most common gynecologic malignancy in the United States. Recent unraveling of the molecular profile of EC and its tumor microenvironment has revealed the immunologic nature of this disease, showing that up to 91% of patients with advanced or recurrent EC have at least one genetic mutation that can serve as an actionable therapeutic target. This activity will provide the most up-to-date information on treatment of EC, particularly in the first line, based on common genetic mutations.

This program is a Twitter-based tutorial designed to provide key information in an accessible format and location


Amir A. Jazaeri, MD
Vice Chair, Clinical Research
Director, Gynecologic Cancer Immunotherapy Program
Professor, Department of Gynecologic Oncology and Reproductive Medicine
University of Texas MD Anderson Cancer Center
Houston, Texas

Martina Murphy, MD (Co-Chair)
Assistant Professor of Medicine
Director, Introduction to Clinical Medicine 1 & 2
Program Director, Hematology/Oncology Fellowship
University of Florida
Gainesville, Florida

Shannon N. Westin, MD, MPH (Co-Chair)
Associate Professor of Medicine
Director, Early Drug Development
Department of Gynecologic Oncology and Reproductive Medicine
University of Texas MD Anderson Cancer Center
Houston, Texas



Release date: January 25, 2021
Expiration date: January 25, 2022
Estimated time to complete activity: 0.25 hour(s)




This program is intended for medical oncologists, gynecologic oncologists, primary care physicians, advanced practice providers, emergency department physicians, and pharmacists involved in the management and treatment of patients with EC.


Upon completion of this educational activity, participants should be able to:

  • Select appropriate and individualized treatment approaches for each EC patient based genomic subtypes and molecular markers

There are no fees for participating and receiving CME credit for this activity. During the period of January 25, 2021 through January 25, 2022, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity on Twitter
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 100%.




Integrity Continuing Education, Inc. is accredited with commendation by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.


Integrity Continuing Education, Inc. designates this other activity for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.


For information about ACCME accreditation of this activity, please contact Integrity Continuing Education at (855) 835-4004 or cme@integrityce.com.


Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Amir A. Jazaeri, MD
Consulting Fees: Gerson Lehrman Group, Guidepoint
Contracted Research: Aravive, AstraZeneca, Bristol-Myers Squibb, Eli Lilly, Genentech, Iovance, Merck
Other (Scientific Advisory Boards): Avenge Bio, Nuprobe, TwoXar
Other (Ad hoc Advisory Boards): Eisai, Genentech-Roche, Iovance, Simcere

Martina Murphy, MD has no real or apparent conflicts of interest to disclose.

Shannon N. Westin, MD, MPH
Consulting Fees: Agenus, AstraZeneca, Circulogene, Clovis Oncology, Eisai, GlaxoSmithKline/Tesaro, Merck, Novartis, Pfizer, Roche/Genentech, Zentalis
Contracted Research: ArQule, AstraZeneca, Bayer, Clovis Oncology, Cotinga Pharmaceuticals, GlaxoSmithKline/Tesaro, Novartis, Roche/Genentech

The Integrity Continuing Education, Inc. planners/managers have nothing to disclose.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number, fax number, and…(continued)


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Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
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For optimal performance, the use of Internet Explorer below 8 is not recommended.
For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below

Click here for more information on minimum system requirements.


The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.


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