Supported by an educational grant from AstraZeneca Pharmaceuticals LP in collaboration with FibroGen.
Patients with CKD and anemia experience substantially increased burdens to morbidity and mortality. The use of erythropoiesis-stimulating agent (ESA) and iron supplementation are mainstays of therapy, yet ESA has been associated with increased cardiovascular adverse events. Furthermore, some patients are resistant to ESA, resulting in higher doses to reach target hemoglobin levels and increasing the risk of adverse events. Increased understanding of hypoxia-inducible factors (HIFs) have led to the development of novel therapies, HIF-PHIs, that work by simulating hypoxia in cells, thereby stimulating EPO synthesis and improving iron metabolism and mobilization through reduced hepcidin levels. Three HIF-PHIs (i.e. roxadustat, vadadustat, and daprodustat) are currently undergoing or have recently completed late-stage development. To be best prepared to incorporate these agents into clinical practice once FDA-approved, nephrologists must be educated on the burdens associated with anemia in CKD, pathophysiological mechanisms involved in CKD-related anemia, and recent outcomes from clinical trials evaluating HIF-PHIs in patients with CKD. This educational activity will address these knowledge gaps among nephrologists, and application of this knowledge will improve outcomes for patients with anemia and CKD.
Martha Gulati, MD, MS, FACC, FAHA, FASPC
Professor of Medicine, Chief of Cardiology
University of Arizona
Daniel Coyne, MD
Professor of Medicine (Division of Nephrology)
Director, Chromalloy American Kidney Center
Director, Medicine Multispecialty Clinics
Washington University School of Medicine
St Louis, Missouri
This educational activity has been designed to meet the needs of nephrologists and other nephrology healthcare professionals, including physician assistants, nurse practitioners, and patients.
Upon completion of this educational activity, participants should be able to:
There are no fees for participating and receiving CME credit for this activity. During the period of February 23, 2021 – February 23, 2022 participants must:
A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 100%.
Physician Continuing Education
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The following faculty/planners reported the financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of these CME activities:
Martha Gulati, MD, MS, FACC, FAHA, FASPC has nothing to disclose.
Daniel W. Coyne, MD
Consulting Fees: Fresenius/Vifor; GSK; Reata; Astra Zeneca; Otsuka; Ardelyx
Expert Witness: Vifor, Patent Litigation
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