Patients with chronic kidney disease (CKD) and anemia experience substantially increased burdens to morbidity and mortality. Erythropoiesis-stimulating agents (ESA) and iron supplementation are mainstays of therapy, yet ESA has been associated with increased cardiovascular adverse events. Increased understanding of hypoxia-inducible factors (HIFs) has led to the development of novel therapies, hypoxia-iducible factor prolyl hydroxylase inhibitors (HIF-PHIs) that work by simulating hypoxia in cells, thereby stimulating EPO synthesis and improving iron metabolism and mobilization through reduced hepcidin levels.
Three HIF-PHIs (i.e. roxadustat, vadadustat, and daprodustat) are currently undergoing late-stage development, with one agent already approved to treat anemia in patients with CKD in China. To be best prepared to incorporate these agents into clinical practice once FDA-approved, nephrologists must be educated on the pathophysiological mechanisms involved in CKD-related anemia and recent outcomes from clinical trials evaluating these agents in patients with CKD. This educational activity will address these knowledge gaps among nephrologists, and application of this knowledge will improve outcomes for patients with anemia and CKD.
Jay B. Wish, MD
Professor of Clinical Medicine
Division of Medicine
Indiana University School of Medicine
This educational activity is intended for nephrology fellows, attendings, and trainees.
Upon completion of this educational activity, participants should be able to:
There are no fees for participating and receiving CME credit for this activity. During the period of September 30, 2020 through September 30, 2021, participants must:
A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 66% or better.
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Jay B. Wish, MD
Consulting Fees: AstraZeneca, Akebia, Vifor, Rockwell Medical
Speakers’ Bureaus: AstraZeneca, Akebia
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Provided by Integrity Continuing Education, Inc.
Supported by an educational grant from AstraZeneca.