Steroids, Surgery, and Biologics, Oh My! Following the Path to Selecting Appropriate Treatments for Individual Patients with CRSwNP

 

 

PROVIDER STATEMENT

Provided by Integrity Continuing Education.

SUPPORTER ACKNOWLEDGEMENT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi Genzyme.

PROGRAM OVERVIEW

Until recently the only treatment choices for patients with CRSwNP, a chronic inflammatory condition of the sinonasal cavities, included saline irrigation for symptomatic relief, local or oral corticosteroids to keep inflammation under control, and polypectomy through endoscopic sinus surgery. Of the upper inflammatory disorders, perhaps the most recalcitrant and refractory is CRSwNP. Nasal polyposis is typically present in patients with the highest levels of disease severity, and endoscopic surgery to remove polyps is not the cure one might presume. Nearly 80% of patients who undergo polypectomy experience polyp recurrence within two years and >35% eventually opt for a second surgery.

Novel biologics that were successful in controlling some forms of severe asthma were put into clinical trials to evaluate their impact on CRSwNP. Availability of biologics for CRSwNP gives clinicians treatment options beyond steroids and surgery for their CRSwNP patients who are struggling to breathe freely. However, it also confronts them with new and different decisions. What criteria should be used in choosing which CRSwNP patients should be prescribed a biologic? Which one should be tried and why? What did clinical trials reveal about their efficacy and safety in CRSwNP? How do I educate and prepare patients for treatment with a biologic? This program is designed to address these and other questions related to the treatment of patients with CRSwNP.

FACULTY

Cecelia C. Damask, DO
Assistant Clinical Professor​
Department of Otolaryngology​
University of Central Florida​
Orlando, Florida

 

Christine B. Franzese, MD
Professor, Director of Allergy​
Department of Otolaryngology​
University of Missouri – Columbia​
Columbia, Missouri

 

Robert M. Naclerio, MD
Otolaryngology-Head and Neck Surgery​
Johns Hopkins University​
Baltimore, Maryland

 

Release date: November 19, 2021
Expiration date: November 19, 2022
Estimated time to complete activity: 75 minutes

 

TARGET AUDIENCE

This educational activity has been designed to meet the needs of otolaryngologists, otolaryngic allergists, and nurse practitioners and physician assistants in otolaryngology specialty practice

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

  • Identify the phenotypes and endotypes of chronic rhinosinusitis with and without nasal polyps based on what is understood thus far about immunologic pathophysiology and its impact on disease burden
  • Summarize the inflammatory targets of biologic treatments for CRSwNP and their efficacy and safety profiles reported in clinical trials
  • Implement appropriate selection criteria for patients with CRSwNP who might benefit from treatment with targeted biologics over steroids or surgery
DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 19, 2021 and November 19, 2022 participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.

MEDIA

Internet

ACCREDITATION

Physician Continuing Education

 

Accreditation Statement
Integrity Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education designates this enduring activity for a maximum of 1.25 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with commercial interests related to the content of these CME activities:

Cecelia C. Damask, DO
Advisory Board: AstraZeneca, Genentech/Novartis, GlaxoSmithKline, Optinose, Regeneron/Sanofi ​
Consultant: Audigy Medical​
Contracted Clinical Research: AstraZeneca, GlaxoSmithKline, Optinose, Regeneron/Sanofi ​
Speakers Bureau: ALK, AstraZeneca, Genentech/Novartis, GlaxoSmithKline, Optinose, Regeneron/Sanofi​

Christine B. Franzese, MD
Advisory Board: GlaxoSmithKline, Sanofi ​
Research Funding: ALK, Bellus, GlaxoSmithKline, Merck, Novartis, Regeneron, Sanofi, Shiniogi ​
Speakers Bureau: ALK, Genentech, GlaxoSmithKline, Novartis, Regeneron, Sanofi​

Robert M. Naclerio, MD
Advisory Board: AstraZeneca, Celgene, GlaxoSmithKline, Lyra Therapeutics, Regeneron, Sanofi

The Integrity Continuing Education planners and managers have nothing to disclose.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
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For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
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DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

 

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