Once considered an inevitable death sentence within a matter of months, multiple myeloma (MM) can now, in many cases, be transformed into a long-term chronic illness that can often be managed for decades. Recent advances in genomics and gene sequencing have led to a better understanding of the myeloma microenvironment in the pathophysiology of MM, which has in turn yielded new therapies that target the diseases through immunomodulatory, cellular, and genetic pathways. Proteasome inhibitors (PIs), specifically, are used across the continuum of care, and have become the backbone of treatment combinations in the relapsed/refractory MM (RRMM) setting, particularly in high-risk disease. However, there is no one standard of care for this disease, due to its complex and nuanced nature. This activity is designed to highlight optimal treatment combinations for standardized case study patients based on a wide variety of patient variabilities, including cytogenetic abnormalities, stage and age at diagnosis, whether and when autologous stem cell transplant (ASCT) might be performed, and multiple other prognostic factors.
Joseph Mikhael, MD, MEd, FRCPC, FACP
Professor, Applied Cancer Research and Drug Discovery
Translational Genomics Research Institute
City of Hope Cancer Center
Chief Medical Officer
International Myeloma Foundation
This educational activity is intended for specialists in hematology (hematologists/oncologists), oncology (medical and radiation oncologists), and physician assistants and nurse practitioners who manage patients with MM.
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Joseph Mikhael, MD, Med, FRCPC, FACP
Consulting Fees: Amgen; Celgene; Karyopharm; Janssen; Sanofi; Takeda
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Supported by an educational grant from Takeda Oncology.