Hiding in Plain Sight? A Focus on Diagnosing and Addressing the Unmet Needs in Homozygous Familial Hypercholesterolemia (HoFH)




This CME activity for ACCME credit is provided by Integrity Continuing Education, Inc.

This CE activity for ANCC and AANP credit is jointly provided by Global Education Group and Integrity Continuing Education, Inc.



This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc.


HoFH is a genetic disorder of lipid metabolism causing severely elevated low-density lipoprotein cholesterol (LDL-C) concentrations that lead to early onset atherosclerotic cardiovascular disease and increased cardiovascular events and mortality. Individuals with HoFH are typically less responsive, or even unresponsive, to standard lipid-lowering therapies such as statins and PCSK9 inhibitors, and may benefit from treatment modalities with other mechanisms of action. This curriculum is designed to educate clinicians about the prevalence of heterozygous familial hypercholesterolemia (HeFH) and HoFH, the importance of screening for familial hypercholesterolemia (FH), and the benefits and limitations of therapies available for lipid management in patients with HoFH. The multidisciplinary faculty of nationally recognized FH experts will provide practical, evidence-based information regarding strategies that increase patient accessibility to newer lipid-lowering therapies.


Martha Gulati, MD, MS, FACC, FAHA, FASPC, FESC
American Society for Preventive Cardiology
Jacksonville, Florida


Kathleen Byrne, MSN, CRNP, FPCNA, CLS, FNLA
Cardiovascular Nurse Practitioner
Adult and Pediatric Cardiology
Johns Hopkins University
Baltimore, Maryland


Release date: February 28, 2022
Expiration date: February 28, 2023
Estimated time to complete activity: 60 minutes



This educational activity has been designed to meet the needs of cardiology physicians, nurse practitioners, physician assistants, nurses, and other healthcare professionals interested in the diagnosis and management of HoFH.


Upon completion of this educational activity, participants should be able to:

  • Describe the prevalence of HoFH and its underdiagnosis
  • Discuss how to apply cascade screening in clinical practice as a cost-effective strategy to diagnose FH in close relatives of patients already diagnosed with FH
  • Outline how to integrate currently available therapies with novel mechanisms of action into the treatment regimen of patients with HoFH
  • Explain how to increase accessibility of newer LDL-C lowering therapies to patients with HoFH

There are no fees for participating and receiving CE/CME credit for this activity. During the period of February 28, 2022 through February 28, 2023, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.




Physician Continuing Education


Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

Credit Designation
Integrity Continuing Education, Inc. designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioner Continuing Education

This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integrity Continuing Education, Inc. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. (This activity is approved for 1.0 contact hour(s) (which includes 0.1 hour(s) of pharmacology).

Nursing Continuing Education
Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This educational activity for 1.0 contact hour is provided by Global Education Group. Nurses should claim only the credit commensurate with the extent of their participation in the activity.


For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about AANP or ANCC accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.


Integrity Continuing Education, Inc. and Global Education Group require instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. and Global Education Group for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CE/CME activities:

Martha Gulati, MD, MS, FACC, FAHA, FASPC, FESC has no real or apparent conflicts of interest to report.

Kathleen Byrne, MSN, CRNP, FPCNA, CLS, FNLA has no real or apparent conflicts of interest to report.

The following project managers/planners: Lindsay Borvansky, Ashley Cann, Samuel Ciociola, Kristin Delisi, NP, Donna Fausak, Andrea Funk, Liddy Knight, Maria Rovere, MTSC, and Rhys Williams, RN, MSN, FNP, reported that they or their spouses/life partners have no financial relationships or relationships to products or devices with commercial interests related to the content of this CE/CME activity.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. and Global Education Group do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)


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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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