Expanding the Role of the Nurse Practitioner in Multiple Sclerosis to Optimize Outcomes: Early Diagnosis, Treatment Advances, and Patient-Centered Care




Multiple Sclerosis (MS) is a progressive, immune-mediated, neurodegenerative disease that is associated with irreversible physical disability and functional impairment. Due to its heterogeneity, treatment of patients with MS is highly individualized. The availability of disease-modifying therapies (DMTs) has revolutionized the care of patients with MS and currently more than a dozen DMTs are FDA-approved, with several more undergoing late-stage clinical trials. However, with no head-to-head trials of DMTs, nurse practitioners (NPs) are dependent upon national guidelines and educational activities to stay abreast of the safety and efficacy of these agents, along with strategies for optimizing patient outcomes. In their multi-faceted roles of administrators, educators, collaborators, consultants, and advocates, NPs are in a position to help identify and manage relapses, symptoms, and treatment-related side effects that all can affect the course of the disease.

This educational activity will address these issues by providing NPs an overview of tools to aid in earlier identification of undiagnosed MS or disease relapse, updates on current and emerging DMTs, and strategies to optimize adherence. Application of the knowledge gained will improve outcomes for patients with MS.


Patricia K. Coyle, MD
Professor and Vice Chair, Clinical Affairs
Director, MS Comprehensive Care Center,
Stony Brook University
Stony Brook, New York


Denise Bruen, ANP-BC, MSN, MSCN
University of Virginia
James Q. Miller Consultative MS Center
Charlottesville, Virginia


Release date: May 26, 2021
Expiration date: May 26, 2022
Estimated time to complete activity: 1 hour



This educational initiative has been designed for nurse practitioners, physician assistants, and physicians who practice in primary care and specialty settings.


Upon completion of this educational activity, participants should be able to:

  • Define the role of the NP in the healthcare setting, and their role in the diagnosis and treatment of multiple sclerosis (MS)
  • Describe how to evaluate patients for signs and symptoms of early MS or relapse, to facilitate prompt referral to specialist care
  • Identify available therapies for treatment of MS, and factors to consider in their use in individual patients
  • Characterize strategies to address patient education and adherence challenges, and the long-term monitoring of overall wellness in patients with MS

There are no fees for participating and receiving CME/CE credit for this activity. During the period of May 26, 2021 through May 26, 2022, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.




Nurse Practitioner Credit Designation


This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integrity Continuing Education, Inc. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 1.0 contact hour (which includes 0.5 hours of pharmacology).


Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation
Integrity Continuing Education, Inc. designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Contact Information
For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about AANP accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.


Integrity Continuing Education, Inc. and Global Education Group requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Patricia K. Coyle, MD
Consulting Fees – Accordant, Biogen, Bristol-Meyers-Squibb, Celgene, Genzme/Sanofi, GlaxoSmithKline, Janssen, Novartis, Viela Bio
Fees for Non-CME/CE Services – Biogen, Janssen
Contracted Research – Actelion, Alkermes, Corrana LLC, MedDay, NINDS, Novartis

Denise Bruen, ANP-BC, MSN, MSCN
Consulting Fees – Biogen, Viela Bio, Novartis, EMD Serono, Genentech/Roche, Genzyme, Janssen

The planners and managers, Michelle R. Rizzo, ELS, and Donna Fausak, hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months. The Global Education Group planners and managers, Kristin Delisi, NP, Lindsay Borvansky, Andrea Funk, Liddy Knight, and Ashley Cann, also have nothing to disclose.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Integrity Continuing Education, Inc. and Global Education Group do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number, fax number, and…(continued)


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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of healthcare professionals relative to diagnostic and treatment options of a specific patient’s medical condition.


This activity is supported by an educational grant from Biogen, Inc.


This CME activity is provided by Integrity Continuing Education, Inc.

This AANP activity is jointly provided by Global Education Group and Integrity Continuing Education, Inc.


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