Patients with CKD and anemia experience substantially increased burdens to morbidity and mortality. The use of erythropoiesis-stimulating agents (ESAs) and iron supplementation are the mainstays of therapy, yet ESA has been associated with increased cardiovascular adverse events. Increased understanding of hypoxia-inducible factors (HIFs) have led to the development of novel therapies, HIF-PHIs, that work by simulating hypoxia in cells, thereby stimulating EPO synthesis and improving iron metabolism and mobilization through recduced hepcidin levels. Four HIF-PHIs are currently undergoing late-stage development, with one agent already approved to treat anemia in patients with CKD in China. It is important that healthcare providers are updated on the clinical trial data of these novel therapies so they are better prepared to integrate these agents in to clinical practice upon FDA approval.
Andrew Howard, MD, FACP
Metropolitan Nephrology Associates
Senior Consultant to the CMO
Fresenius Kidney Care
This activity is intended for nephrology specialty HCPs that manage patients with anemia in CKD.
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Andrew Howard, MD, FACP
Consulting: Fresenius Kidney Care
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