Cognitive Impairment Associated With Schizophrenia: Evaluating Emerging Therapies

Course Information
Release date: December 18, 2024
Expiration date: December 18, 2025
Estimated time to complete activity: 60 minutes
PROVIDER STATEMENT

This activity is provided by Integrity CE, LLC.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical educational grant from Boehringer Ingelheim Pharmaceuticals, Inc.

PROGRAM OVERVIEW

Cognitive impairment associated with schizophrenia (CIAS) is a core symptom domain of schizophrenia that can impose even greater long-term damage than the delusions and hallucinations this psychiatric disorder is known for. CIAS, which is marked by impairments in neurocognition and social cognition, can start in early childhood — long before any signs of psychosis. For many patients, functional outcomes are so compromised that performing activities of daily life and living independently are impossible. One therapy in late-phase development is showing promise for CIAS as an add-on treatment to standard-of-care antipsychotics.

Learning Objectives
TARGET AUDIENCE

This educational activity has been designed to meet the needs of psychiatrists, psychiatry mental health therapists (eg, psychologists, social workers, case managers), nurse practitioners, physician assistants, pharmacists, primary care providers, and other clinicians involved in the management of patients with CIAS.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

  • Characterize the disease burden and unmet treatment needs of patients with CIAS
  • Explain what is known about the pathophysiology of CIAS and how its symptoms differ from those in the negative domain
  • Select an emerging therapeutic agent for patients affected by CIAS based on safety, efficacy, and mechanism of action
Faculty Information and Disclosures

FACULTY

John H. Krystal, MD
Robert L. McNeil, Jr. Professor of Translational Research
Chair, Yale Department of Psychiatry
Chief of Psychiatry, Yale-New Haven Hospital
Co-Director, Yale Center for Clinical Investigation
New Haven, Connecticut
Stephen R. Marder, MD
Distinguished Professor of Psychiatry
Semel Institute for Neuroscience at UCLA
Director, VA Desert Pacific Mental Illness Research, Education, and Clinical Center
Los Angeles, California

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity CE, LLC requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity CE, LLC for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

John H. Krystal, MD
Consultant: AbbVie, Inc, Biogen, Idec, MA, Bionomics, Limited (Australia), BioXcel Therapeutics, Boehringer Ingelheim International, Cerevel Therapeutics, LLC, Clearmind Medicine, Inc., Cybin IRL, EpiVario, Inc., Janssen Pharmaceutical, Jazz Pharmaceuticals, Inc., Leal Therapeutics, Inc., Manifest Technologies, MycoMedica Life Sciences, PBC, Neurocrine Biosciences, Inc., Novartis Pharmaceuticals, Otsuka America Pharmaceutical, Inc., Praxis Precision Medicines, Inc., Psylo PTY LTD., Response Pharmaceuticals, Inc., Reunion Neuroscience, Spring Care, Inc., Takeda Pharmaceuticals, International, Terran Biosciences, Inc., Tetricus, Inc., WebMD/Medscape, LLC
Scientific Advisory Board: Biogen, Idec, MA, Biohaven Pharmaceuticals, BioXcel Therapeutics, Inc. (Clinical Advisory Board), Cerevel Therapeutics, LLC, Certigo Therapeutics, Inc, Clearmind Medicine, Inc., Coalition for Aligning Science, Delix Therapeutics, Inc., EpiVario, Inc., Freedom Biosciences, Inc., Mindset Admin, LLC (DBA Being Health), MycoMedica Life Sciences, PBC (PMDD Advisory Board), Neumora Therapeutics, Inc., Neurocrine Biosciences, Inc., Novartis Pharmaceuticals Corporation, Praxis Precision Medicines, Inc., PsychoGenics, Inc., Response Pharmaceuticals, Inc., ReST Therapeutics, Takeda Industries, Terran Biosciences, Inc., Tetricus, Inc. ​
Stock: Biohaven Pharmaceuticals, Spring Care, Inc. ​
Stock Options: Biohaven Pharmaceuticals Medical Sciences, Clearmind Medicine, Inc., Delix Therapeutics, Inc., EpiVario, Inc., Manifest Technologies, Neumora Therapeutics, Inc., Psylo PTY LTD., ReST Therapeutics, Spring Care, Tempero Bio, Inc., Terran Biosciences, Inc., Tetricus, Inc.

Steven R. Marder, MD
Consultation: Boehringer Ingelheim, Karuna, Merck, Newron, Sunovion
Research: Boehringer Ingelheim

The Integrity CE, LLC planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

Accreditation Information
DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of December 18, 2024 through December 18, 2025, participants must:

  • Read the learning objectives
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 60% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity CE, LLC is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity CE, LLC designates this enduring material for a maximum of 1.0 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity CE, LLC at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity CE, LLC does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimers and Technical Requirements
MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity CE, LLC, you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe® Flash® Player 10

  • Adobe® Flash® Player 10 plug-in should be downloaded
  • Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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