Breaking Free from the Grasp of Seasonal Influenza: Key Diagnostic and Management Considerations on the Front Lines of Care




Every year, seasonal influenza is a significant cause of mortality among at-risk populations, elderly individuals, pregnant women, and children under 2 years of age. In light of the coronavirus disease (COVID-19) pandemic, there is wide-spread apprehension regarding effective prevention and management of seasonal influenza during 2021-2022. Concurrent influenza and COVID-19 outbreaks could further critically overwhelm healthcare systems and drain resources, thereby exponentially increasing their burden. Therefore, overcoming existing and new barriers related to the best practice management of influenza is of high priority.  Given that nurse practitioners (NPs) and physician assistants (PAs) can aid in reducing influenza-associated morbidity and mortality, it is crucial that these professionals are well-prepared to vaccinate, diagnose, and treat patients that are at risk for developing or have seasonal influenza.

This activity will address knowledge and competence gaps regarding the prevention and management of influenza and ensure that influenza outbreaks are not missed or ignored during the COVID-19 pandemic.


William A. Fischer II, MD
Associate Professor of Medicine
Division of Pulmonary and Critical Care Medicine
Institute of Global Health and Infectious Diseases
University of North Carolina School of Medicine
Chapel Hill, North Carolina


Ryan Holley-Mallo, PhD, DNP, NP-C, FAANP
Associate Professor, Graduate Nursing
Averett University
Nurse Practitioner in Family Medicine
Catherine’s Health Center
Grand Rapids, Michigan


Release date: May 26, 2021
Expiration date: May 26, 2022
Estimated time to complete activity: 1.0 hour



This educational initiative has been designed for nurse practitioners, physician assistants, and physicians who practice in primary care and specialty settings.


Upon completion of this educational activity, participants should be able to:

  • Articulate the role of vaccination in reducing the spread of influenza and improving patient outcomes while emphasizing the importance of vaccination during the COVID-19 pandemic
  • Describe how to implement updated guidelines to differentially diagnose influenza in order to initiate early and appropriate therapy
  • Discuss how to utilize antiviral chemoprophylaxis in appropriate individuals at high risk of developing influenza and associated complications
  • Interpret existing and new evidence with traditional and new influenza treatments, including differences in efficacy and safety, dosage and administration, and reduction in disease burden and complications
  • Outline how to individualize flu treatment with antiviral medications among diverse patients

There are no fees for participating and receiving CME/CE credit for this activity. During the period of May 26, 2021 through May 26, 2022, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.




Nurse Practitioner Credit Designation


This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integrity Continuing Education. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 1.0 contact hour (which includes 0.5 hours of pharmacology).


Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

Credit Designation
Integrity Continuing Education, Inc. designates this enduring activity for a maximum of 1.0 AMA PRA Category 1 Credit. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Contact Information
For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or

For information about AANP accreditation of this activity, please contact Global Education Group at (303) 395-1782 or


Integrity Continuing Education, Inc. and Global Education Group requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

William A. Fischer II, MD
Research support – Ridgeback Biopharmaceuticals
Consultant – Roche and Merck
Served on adjudication panel for Janssen and Syneos

Ryan Holley-Mallo, PhD, DNP, NP-C, FAANP
No real or apparent conflicts of interest to disclose.

The planners and managers, Michelle R. Rizzo, ELS, and Donna Fausak, hereby state that they or their spouse/life partner do not have any financial relationships or relationships to products or devices with any commercial interest related to the content of this activity of any amount during the past 12 months. The Global Education Group planners and managers, Kristin Delisi, NP, Lindsay Borvansky, Andrea Funk, Liddy Knight, and Ashley Cann, also have nothing to disclose.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the US Food and Drug Administration. Integrity Continuing Education, Inc. and Global Education Group do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number, fax number, and…(continued)


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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of healthcare professionals relative to diagnostic and treatment options of a specific patient’s medical condition.


This activity is supported by an educational grant from Genentech, a member of the Roche Group.


This CME activity is provided by Integrity Continuing Education, Inc.

This AANP activity is jointly provided by Global Education Group and Integrity Continuing Education, Inc.


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