A Light in the Darkness: Advances in Systemic Lupus Erythematosus




This CME activity for ACCME and AAPA credit is provided by Integrity Continuing Education, Inc.

This CE activity for AANP credit is jointly provided by Global Education Group and Integrity Continuing Education, Inc.


This activity is supported by an education grant from AstraZeneca Pharmaceuticals.


Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disorder associated with significant morbidity and mortality, which impacts quality of life and life expectancy. Therapeutic strategies rely heavily on the use of corticosteroids to control inflammation; however, chronic use of these agents is responsible for much of the long-term damage accrual in SLE. Alongside corticosteroids, immunomodulators (hydroxychloroquine and vitamin D) should be maximized, and active disease should be controlled with immunosuppression or biologics when required.  Due to the lack of standardized, objective clinical measures, rheumatology clinicians may delay escalation to an advanced therapy, causing many patients to linger unnecessarily on first-line therapies.

This activity will address evolving clinical evaluation tools and rating instruments that are necessary to fully understand clinical trial outcomes, integrate emerging treatments into clinical practice, and identify patients who would benefit most from these novel therapies.


Sheetal Desai, MD, MSEd
Associate Professor
Department of Rheumatology
University of California, Irvine
Orange, California


Release date: March 31, 2022
Expiration date: March 31, 2023
Estimated time to complete activity: 45 minutes



This educational activity has been designed to meet the needs of rheumatologists, nurse practitioners, and physician assistants involved in the management of patients with SLE.


Upon completion of this educational activity, participants should be able to:

  • DEMONSTRATE how to apply current evidence to the effective management of SLE
  • DESCRIBE current and emerging clinical evaluation tools and rating instruments used in clinical trials and/or clinical practice for patients with SLE
  • DISCUSS the utility of patient-centered shared decision-making and patient-reported outcomes in improving adherence and quality of life in patients with SLE
  • REVIEW mechanisms of action and outcomes data from recent clinical trials on new and emerging SLE targeted therapies

There are no fees for participating and receiving CE/CME credit for this activity. During the period of March, 31, 2022 through March, 31, 2023, participants must:

  • Read the learning objectives and faculty disclosures
  • Complete the pretest
  • Study the educational activity
  • Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form and a completed posttest with a score of 70% or better.

Successful completion of the posttest is required to earn AAPA Category 1 CME credit. Successful completion is defined as a cumulative score of at least 70 percent correct.




Physician Continuing Education

Accreditation Statement
Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.


Integrity Continuing Education, Inc. designates this enduring activity for a maximum of 0.75 AMA PRA Category 1 CreditTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioner Continuing Education

This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integrity Continuing Education, Inc. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 0.75 contact hour(s) (which includes 0.2 hour(s) of pharmacology).

Physician Assistant Continuing Education (AAPA)

This activity has been reviewed by the AAPA Review Panel and is compliant with AAPA CME Criteria. This activity is designated for 0.75 AAPA Category 1 CME credits. Approval is valid from 3/31/2022 to 3/31/2023. PAs should only claim credit commensurate with the extent of their participation. AAPA reference number: CME-204547.


For information about ACCME or AAPA accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about AANP accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.


Integrity Continuing Education, Inc. and Global Education Group require instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any real or apparent conflict of interest they may have as related to the content of this activity. All identified conflicts of interest are thoroughly vetted by Integrity Continuing Education, Inc. and Global Education Group, for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CE/CME activities:

Sheetal Desai, MD, MSEd
Consulting: AstraZeneca, Aurinia Pharmaceuticals Inc., GlaxoSmithKline, Janssen Pharmaceuticals

Dave Mittman, DMSc (h.d.), PA, DFAAPA (Peer Reviewer) has no real or apparent conflicts of interest to report.

The following project managers/planners: Olivia Benevento, Stefani Chiarolanza, Lindsay Borvansky, Ashley Cann, Kristin Delisi, NP, Donna Fausak, Andrea Funk, Liddy Knight, and Patima Tanapat, PhD, reported that they have no financial relationships or relationships to products or devices with ineligible companies related to the content of this CE/CME activity.


This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. and Global Education Group, do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)


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Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
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  • Adobe® Flash® Player 10 plug-in should be downloaded
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For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
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The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

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