TITLE OF ACTIVITY:

2024 Johns Hopkins Updates in Gastrointestinal Cancers

PRESENTED BY:

Johns Hopkins University School of Medicine and Integrity Continuing Education, Inc.

DESCRIPTION

Don’t miss this free opportunity to hear the latest updates from the experts! This activity will address the newest data and updates across gastrointestinal (GI) cancers and neuroendocrine tumors (NETs) for the multidisciplinary team of medical, surgical and, radiation oncologists who treat and manage these patients. Clinicians will be given the opportunity to claim up to 8.5 credit hours.

WHO SHOULD PARTICIPATE

This activity is intended for medical, surgical and radiation oncologists, physician assistants, nurse practitioners, nurses and other specialists who treat and manage patients with gastrointestinal cancers.

OBJECTIVES

After participating in this activity, the learner will demonstrate the ability to:

Display increased awareness of the new agents in late-stage development
Provide guidance on multidisciplinary care that centers on patient outcomes
Evaluate the efficacy and safety of biomarker-targeted therapies in late-stage clinical trials.

ACCREDITATION STATEMENT

The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT

The Johns Hopkins University School of Medicine Office of Continuing Medical Education designates this enduring material for a maximum of 8.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

POLICY ON PRESENTER AND PROVIDER DISCLOSURE

It is the policy of the Johns Hopkins School of Medicine (and the Institute for Johns Hopkins Nursing) that the presenter and provider globally disclose conflicts of interest. The Johns Hopkins School of Medicine OCME has established policies in place to identify and mitigate relevant conflicts of interest prior to this educational activity. Detailed disclosure will be made prior to presentation of the education.

NOTICE ABOUT OFF-LABEL USE PRESENTATIONS

The Johns Hopkins School of Medicine/Johns Hopkins Updates in GI Cancers Conference may include presentations on drugs or devices, or use of drugs or devices, that have not been approved by the Food and Drug Administration (FDA) or have been approved by the FDA for specific uses only. The FDA has stated that it is the responsibility of the physician to determine the FDA clearance status of each drug or device he or she wishes to use in clinical practice. The Johns Hopkins School of Medicine is committed to the free exchange of medical education. Inclusion of any presentation in this program, including presentations on off-label uses, does not imply an endorsement by Johns Hopkins of the uses, products, or techniques presented.

JOHNS HOPKINS STATEMENT OF RESPONSIBILITY

The Johns Hopkins School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

COPYRIGHT

All rights reserved - The Johns Hopkins School of Medicine. No part of this program may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embodied in articles or reviews.

COURSE FORMAT – METHOD OF PARTICIPATION

This enduring material is expected to take approximately 8.5 hours to complete. Once the activity is completed, you must pass the post-test and complete the evaluation with attestation to receive CME credit.

HOW TO OBTAIN CME CREDIT

View the content and complete the post-test and evaluation. The content is available at: <INSERT VUMEDI LINK>

PREREQUISITES FOR PARTICIPANTS

There are no prerequisites to participate in this activity.

HARDWARE/SOFTWARE REQUIREMENTS

Internet connection.

POST-TEST

A post-test will be conducted at the conclusion of the activity. A grade of at least 66% within three attempts is needed to receive CME credit.

RELEASE DATE

March 27, 2024

EXPIRATION DATE

March 27, 2025

WHAT YOU SHOULD KNOW ABOUT GIFTS TO PHYSICIANS FROM INDUSTRY

Gift giving from the pharmaceutical, device and medical equipment industries to physicians has long been a customary practice. But when gift giving is not practiced within established ethical boundaries, the perception of conflict of interest is raised. All physicians and physicians in training should adhere to the AMA Code of Medical Ethics, Opinion 8.061, “Gifts to Physicians from Industry” which can be found under the AMA Code of Medical Ethics at www.ama-assn.org/go/ethicalgifts. Johns Hopkins faculty, staff, employees, students, and trainees must adhere to the more restrictive Johns Hopkins Medicine Policy on Interaction with Industry that can be found on HopkinsMedicine.org by clicking Research > For Our Researchers > Research Affairs Offices > Office of Policy Coordination > Policy on Interaction with Industry or directly through this link http://www.hopkinsmedicine.org/Research/OPC/Policy_Industry_Interaction.

DISCLAIMER STATEMENT

The opinions and recommendations expressed by faculty and other experts whose input is included in this program are their own. This [insert activity format] is produced for educational purposes only. Use of the Johns Hopkins University School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combination of drugs, including indications, contraindications, warnings, and adverse effects before administering pharmacologic therapy to patients.

CONFIDENTIALITY DISCLAIMER FOR CME ACTIVITY PARTICIPANTS

I certify that I am participating in a Johns Hopkins University School of Medicine CME activity for accredited training and/or educational purposes. I understand that while I am participating in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the Privacy Regulations). Protected health information is information about a person's health or treatment that identifies the person. I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos on any social medial site (e.g. Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device. I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is Johns Hopkins Privacy Officer, telephone: 410-735-6509, e-mail: HIPAA@jhmi.edu. "The Office of Continuing Medical Education at The Johns Hopkins University School of Medicine, as provider of this activity, has relayed information with the CME attendees/participants and certifies that the visitor is attending for training, education and/or observation purposes only." For CME questions, please contact the CME Office (410) 955-2959 or e-mail cmenet@jhmi.edu. For certificates, please call (410) 502-9636. Johns Hopkins University School of Medicine Office of Continuing Medical Education Turner 20/720 Rutland Avenue Baltimore, Maryland 21205-2195 Reviewed & Approved by: General Counsel, Johns Hopkins Medicine (4/1/03) (Updated 4/09 and 3/14)

MITIGATION OF RELEVANT FINANCIAL RELATIONSHIPS

Johns Hopkins University adheres to the ACCME’s Standards for Integrity and Independence in Accredited Continuing Education. Any individuals in a position to control the content of a CE activity, including faculty, planners, reviewers or others are required to disclose all relevant financial relationships with ineligible entities (commercial interests). All relevant conflicts of interest have been

mitigated prior to the commencement of the activity.

FULL DISCLOSURE POLICY AFFECTING CME ACTIVITIES

As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), Johns Hopkins University School of Medicine Office of Continuing Medical Education (OCME) requires attested and signed global disclosure of the existence of all financial interests or relationships with ineligible companies from any individual in a position to control the content of a CME activity sponsored by OCME. The following relationships have been reported for this activity: Ana de Jesus Acosta, MD Disclosures: Consultant: Merck and Company, Inc. Grant or Research Support: AstraZeneca Marina Baretti, MD Disclosures: Advisor: AstraZeneca, Exelixis Katherine Meryl Bever, MD Disclosures: Grant or Research Support: Bristol-Myers Squibb, Merck and Company, Inc. Nikhil Bhagat, MD has no relevant financial interest or relationship with ineligible companies. Jaqueline Elizabeth Birkman-Gartman, MD has no relevant financial interest or relationship with ineligible companies. William Reece Burns III, MD has no relevant financial interest or relationship with ineligible companies. Eric Scott Christenson, MD Disclosures: Consultant: Seres Therapeutics, Sex Grant or Research Support: Affimed GmbH, Haystack, NextCure, Pfizer, Regeneron Freddy E. Escorcia, MD, PhD has no relevant financial interest or relationship with ineligible companies. James J. Harding, MD Disclosures: Advisor: AstraZeneca, Boehringer Ingelheim Vetmedica GmbH., Bristol-Myers Squibb, Eisai, Inc., LightLa Imaging, Inc. Jonathan M. Hernandez, MD Disclosures: Grant or Research Support: AVEO Oncology, Boehringer Ingelheim Vetmedica GmbH, Travera David Hsieh, MD Disclosures: Grant or Research Support: Arcus Margaret Geraldine Keane, M.B.B.S., M.Sc. has no relevant financial interest or relationship with ineligible companies. Alodia Gabre Kidan, MD has no relevant financial interest or relationship with ineligible companies. Sam Klempner, MD Disclosures: Consultant: AstraZeneca, Bristol-Myers Squibb, Daiichi Sankyo, Eli Lilly and Company, Merck and Company, Inc., Mersana, Novartis AG, Sanofi-Aventis, Servier Grant or Research Support: Merck and Company, Inc. Honoraria: TerSera Rachit Kumar, MD has no relevant financial interest or relationship with ineligible companies. Kelly Jeanne Lafaro, MD, MPH has no relevant financial interest or relationship with ineligible companies. Valerie Lee, MD Disclosures: Grant or Research Support: Boston Scientific Corporation, Flavocure, Nanocan Robert Partick Liddell, M.B.B.Ch., MS has no relevant financial interest or relationship with ineligible companies. Eric Liu, MD, FACS Disclosures: Consultant: AstraZeneca, Ideaya, Merck and Company, Inc., Merus, Seagen Mari Nakazawa, MD has no relevant financial interest or relationship with ineligible companies. Amol Narang, MD Disclosures: Other relevant financial or material interests/Travel: Astellas, RenovoRx Michael Pishvaian, MD, PhD Disclosures: Honoraria: Novartis AG, Pfizer, Inc. Membership on Advisory Committees or Review Panels, Board Membershp, etc.: Astellas, TriSalus Stocks or stock options, excluding diversified mutual funds: Perthera Ownership, including stock or stock option ownership in privately held: Tumor Board Tuesday, TRICC Grant or research support: Actuate, Amgen, Arcus Bio, Astellas, Biomed Valley Discoveries, Boehringer Ingelheim, Hutchison Medipharma, Ideaya, MEI Pharma, Merck and Company, Inc., Novartis AG, Pfizer, Inc., RenovoRX, Repare, Seagen, Tizona, Takeda Pharmaceuticals, Tesaro Consultant: AstraZeneca, Ideaya, Merck and Company, Inc., Merus, Seattle Genetics Ashwani Rajput, MD has no relevant financial interest or relationship with ineligible companies. Kim A. Reiss-Binder, MD Disclosures: Membership on Advisory Committees or Review Panels, Board Membership, etc.: AstraZeneca, Bristol-Myers Squibb, MS, Carisma Therapeutics, FoundationOne Christopher Shubert, MD Disclosures: Consultant: Cancer Study Group Lilja Bjork Solnes, MD, MBA Disclosures: Grant or research support: AAA, Cellectar, Novartis AG, PMI, Progenics Consultant: Lantheus, Progenics Royalties or Patent Beneficiary: Elsevier Jonathan Strosberg, MD Disclosures: Grant or research support: AlphaMedix, ITM, RayzeBio Khinh Ranh Voong, MD, MPH has no relevant financial interest or relationship with ineligible companies. Emily R. Winslow, MD has no relevant financial interest or relationship with ineligible companies. Mark Yarchoan, MD Disclosures: Consultant: AstraZeneca, Eisai Inc., Exelixis, Hepion, Lantheus, Replimune Grant or research support: Bristol-Meyers Squibb, Exelixis, Genentech Inc., Incyte Daniel James Zabransky, MD, PhD Disclosures: Grant or research support: Amgen, BMS, Bioscan, Inc., Halozyme, iTeos, Merck and Company, Inc., NovaRock Neeha Zaidi, MD Disclosures: Advisor: Alphamab, BioArdis, Biosion, Fortress Biotech, Mingruizhiyao, Novagenesis, QED, Xilio Lei Zheng, MD, PhD Disclosures: Consultant: Ambrx, NovoRock, Pfizer, Snow Lake Capitals Stock or stock options (excluding diversified mutual funds): Alphamab, Biosion, Mingruizhiyao No one else in a position to control the content of this educational activity has disclosed a relevant financial interest or relationship with ineligible companies. All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

ACKNOWLEDGEMENT

We wish to acknowledge the following companies that have provided or pledged an educational grant in support of this activity. Please note that commercial support received is solely for the educational component of the activity and will not be used to provide food and beverage. • AstraZeneca Pharmaceuticals • Beigene • Exelixis • Pfizer • Taiho Please note: The Physician Payments Sunshine Act was enacted by Congress to increase public awareness of financial relationships between drug and medical device manufacturers and physicians.  In compliance with the requirements of this Act, the commercial supporter/s of this activity may require the Johns Hopkins School of Medicine to report certain professional information (such as name, address, National Provider Identifier (NPI), and State License number) of physician attendees who receive complimentary food and beverage in conjunction with a CME activity.  The commercial supporter is required to submit the collected data to the Centers for Medicare and Medicaid Services which will then publish the data on its website.

LIST FACULTY NAMES/CREDENTIALS/AFFILIATIONS

Ana de Jesus Acosta, MD Associate Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Marina Baretti, MD Assistant Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Katherine Meryl Bever, MD Assistant Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Nikhil Bhagat, MD Johns Hopkins University School of Medicine Baltimore, MD Jacqueline Elizabeth Birkman-Gartman, MD Assistant Program Director, Gastrointestinal and Liver Pathology Advanced Specialty Fellowship Training Program Assistant Professor of Pathology Johns Hopkins University School of Medicine Baltimore, MD William Reece Burns III, MD Assistant Professor of Surgery Johns Hopkins University School of Medicine Baltimore, MD Eric Scott Christenson, M.D. Assistant Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Freddy E. Escorcia, M.D., Ph.D. Radiation Oncologist Veterans Affairs Medical Center Baltimore, MD Investigator, Lasker Clinical Research Scholar Molecular Imaging Branch and Radiation Oncology Branch, Center for Cancer Research National Cancer Institute, NIH Bethesda, MD James J. Harding, MD Gastrointestinal Oncologist & Early Drug Development Specialist Memorial Sloan Kettering Cancer Center New York, NY Jonathan M. Hernandez, M.D. Investigator, Surgical Oncology Program National Institutes of Health Bethesda, MD David Hsieh, MD Assistant Professor Division of Hematology and Oncology UT Southwestern Medical Center Dallas, TX Margaret Geraldine Keane, M.B.B.S., M.Sc. Assistant Professor of Medicine Johns Hopkins University School of Medicine Baltimore, MD Alodia Gabre Kidan, MD Director, Surgery Clerkship Assistant Professor of Surgery Johns Hopkins University School of Medicine Baltimore, MD Sam Klempner, MD Medical Oncologist Mass General Cancer Center Massachusetts General Hospital Boston, MA Rachit Kumar, MD Assistant Professor of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine Baltimore, MD Kelly Jeanne Lafaro, M.D., M.P.H. Assistant Professor of Surgery Johns Hopkins University School of Medicine Baltimore, MD Valerie Lee, MD Assistant Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Robert Patrick Liddell, M.B.B.Ch., M.S. Director, Interventional Radiology Associate Professor of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD Eric Liu, MD, FACS Surgical Director The Neuroendocrine Institute Rocky Mountain Cancer Centers Denver, CO Mari Nakazawa, MD Fellow Johns Hopkins University School of Medicine Baltimore, MD Amol Narang, MD Assistant Professor Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine Baltimore, MD Michael Pishvaian, MD, PhD Director of Gastrointestinal, Developmental Therapeutics and Clinical Research Programs Johns Hopkins Kimmel Cancer Center at Sibley Memorial Hospital Johns Hopkins University School of Medicine Washington, DC Ashwani Rajput, MD Director, Johns Hopkins Kimmel Cancer Center - National Capital Region Professor of Surgery Johns Hopkins University School of Medicine Baltimore, MD Kim A. Reiss-Binder, MD Assistant Program Director of the Hematology/Oncology Fellowship Program Associate Professor of Medicine (Hematology-Oncology) Hospital of the University of Pennsylvania Philadelphia, PA Christopher Shubert, MD Assistant Professor of Surgery Johns Hopkins University School of Medicine Baltimore, MD Lilja Bjork Solnes, MD, MBA Director, Nuclear Medicine and Molecular Imaging Associate Professor of Radiology and Radiological Science Johns Hopkins University School of Medicine Baltimore, MD Jonathan Strosberg, MD Professor Moffitt Cancer Center Tampa, FL Khinh Ranh Voong, MD, MPH Program Director of the Department of Radiation Oncology Residency Program Assistant Professor of Radiation Oncology and Molecular Radiation Sciences Johns Hopkins University School of Medicine Baltimore, MD Emily R. Winslow, MD Transplant Surgeon Washington, DC Mark Yarchoan, MD Associate Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Daniel James Zabransky, M.D., Ph.D. Assistant Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Neeha Zaidi, MD Assistant Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD Lei Zheng, MD, PhD Co-Director, Pancreatic Cancer Precision Medicine Center of Excellence Program Professor of Oncology Johns Hopkins University School of Medicine Baltimore, MD

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