Release date: December 1, 2023
Expiration date: December 1, 2024
Estimated time to complete activity: 30 minutes

PROVIDER STATEMENT

Provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

Supported by educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

This activity, Clinical Updates in Non-Small Cell Lung Cancer from Madrid, features expert faculty Dr. Ticiana Leal discussing the most important and clinically relevant data and framing it for integration into clinical practice.

Abstracts included in this presentation include:

• LBA5 – Amivantamab Plus Chemotherapy vs Chemotherapy as First-line Treatment in EGFR Exon 20 Insertion-mutated Advanced Non-small Cell Lung Cancer (NSCLC): Primary Results From PAPILLON, a Randomized Phase 3 Global Study (Girad)
• LBA14 – Amivantamab Plus Lazertinib vs Osimertinib as First-line Treatment in Patients With EGFR-mutated, Advanced Non-small Cell Lung Cancer (NSCLC): Primary Results From MARIPOSA, a Phase 3, Global, Randomized, Controlled Trial (Byoung Chul Cho )
• LBA15 – Amivantamab Plus Chemotherapy (With or Without Lazertinib) vs Chemotherapy in EGFR-mutated Advanced NSCLC After Progression on Osimertinib: MARIPOSA-2, a Phase 3, Global, Randomized, Controlled Trial (Passaro)
• LBA12 – Datopotamab deruxtecan (Dato-DXd) vs docetaxel in previously treated advanced/metastatic (adv/met) non-small cell lung cancer (NSCLC): results of the randomized phase 3 study TROPION-Lung01 (Lisberg)
• LBA56 – Overall survival in the KEYNOTE-671 study of perioperative pembrolizumab for early-stage non-small-cell lung cancer (NSCLC)

TARGET AUDIENCE

This educational activity was designed for community based medical oncologists and other healthcare providers that treat and manage patients with cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Compare and contrast new and emerging therapies with established treatment options

FACULTY CHAIR

Ticiana Leal, MD Associate Professor Department of Hematology/Oncology Director, Thoracic Medical Oncology Program Winship Cancer Institute Emory University Atlanta, Georgia

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Ticiana Leal, MD
Advisory board: AstraZeneca, Bayer, BeyondSpring, Blueprint, Boehringer-Ingelheim, Bristol-Myers Squibb, EMD Serono, Genentech, InvisionFirst Lung, Janssen, Jazz, Merck, Takeda
Consultant: AstraZeneca, Boehringer-Ingelheim, Genentech, Janssen, Jazz, Lilly

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of December 1, 2023 through December 1, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 33% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: December 8, 2023
Expiration date: June 8, 2024
Estimated time to complete activity: 1 hour

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by an educational grant from GSK.

PROGRAM OVERVIEW

This educational initiative focuses on improving knowledge of respiratory syncytial virus (RSV) as a pathogen in older adults and the burden of the disease associated with the virus, RSV diagnosis and prevention strategies (including hygiene and vaccination), and data on the safety and efficacy of emerging vaccines. Additionally, expert faculty will provide insight on improving competence to incorporate vaccines into a multidisciplinary approach to healthy aging, with emphasis on the need to increase the rate of vaccination in older adults.

TARGET AUDIENCE

This educational activity has been designed to meet the needs of physicians, physician assistants, nurse practitioners, respiratory therapists, and nurses involved in the management of older adults.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Discuss the burden, risk factors, and diagnosis of RSV in adults
• Review RSV prevention strategies, including hygiene and vaccination, and discuss the efficacy and safety of emerging vaccines for RSV
• Implement strategies to improve vaccine uptake in adults as part of a multidisciplinary approach to healthy aging

FACULTY

Antonio Anzueto MD Professor Medicine Pulmonary/Critical Care Medicine University of Texas Health Science Center at San Antonio San Antonio, Texas

Emily Toth, PhD, MPH Associate Professor Epidemiology University of Michigan School of Public Health Ann Arbor, Michigan

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Emily Toth Martin, MPH, PhD
Research Funds (Institution): Merck

Antonio Anzueto, MD
Advisory Board: AstraZeneca, Boehringer Ingelheim, GSK, Novartis, Pfizer, Verona Pharma
Consultant: AstraZeneca, Boehringer Ingelheim, GSK, Novartis, Pfizer, Verona Pharma

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of December 8, 2023 through June 8, 2023 participants must:

• Read the learning objectives and faculty disclosures
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 60% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 30, 2023
Expiration date: November 30, 2024
Estimated time to complete activity: 60 minutes

PROVIDER STATEMENT

This CME activity for ACCME credit is provided by Integrity Continuing Education, Inc.
This CE activity for ANCC and AANP credit is jointly provided by Global Education Group and Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from GRAIL, LLC.

PROGRAM OVERVIEW

Early detection of cancer provides a critical opportunity to alter the course of disease, improving health measures and reducing overall cancer-related mortality. Nevertheless, significant shortcomings in early detection remain persistent, leaving many patients vulnerable to poor outcomes. While suboptimal screening practices are attributable to multiple factors, a key barrier is the limited number of cancer types for which screening methods are available, as well as inadequacies linked to health and sociodemographic disparities, and challenges in patient engagement related to preferences, values, and logistical concerns.

Nurse practitioners (NPs) and advanced practice nurses (APNs) play a critical role in health care delivery across a range of settings and are essential to bettering patient outcomes in many communities, particularly rural and underserved areas. Moreover, studies have shown that educational intervention for NPs and APNs on current cancer screening recommendations increases not only knowledge, but also actual rates of screening.

With this in mind, our program has been designed to provide NPs and APNs with the knowledge and skills needed to implement effective screening practices, including the use of novel technologies.

TARGET AUDIENCE

This educational activity has been designed to meet the needs of nurse practitioners, advanced practice nurses, and physician assistants in primary care and specialty settings.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Describe the science that underlies multi-cancer screening tests and the rationale for their application
• Differentiate among new and emerging blood-based multi-cancer screening tests
• Employ strategies to reduce barriers to effective population-scale cancer screening, including health and sociodemographic disparities, and challenges in patient engagement
• Utilize cancer screening integration tools that increase patient engagement, improve patient outcomes, and promote continuity of care

FACULTY

Leigh Simpson, NP Internal Medicine Nurse Practitioner Intermountain Healthcare Sandy, Utah

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CE/CME activity:

Leigh Simpson, NP has reported no financial relationships or relationships to products or devices with ineligible companies related to the content of this CE activity.

The Integrity Continuing Education, Inc. and the Global Education Group planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CE/CME credit for this activity. During the period of November 30, 2023 through November 30, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 60% or better and a completed activity evaluation form.

ACCREDITATION

Physician Continuing Education

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioner Continuing Education

This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integrity Continuing Education. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 1.0 contact hour (which includes 0.0 hour(s) of pharmacology).

Nursing Continuing Education

Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This educational activity for 1.0 contact hour including 0.0 pharmacotherapeutic contact hour(s).  Nurses should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about AANP or ANCC accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 30, 2023
Expiration date: November 30, 2024
Estimated time to complete activity: 60 minutes

PROVIDER STATEMENT

This CME activity for ACCME credit is provided by Integrity Continuing Education, Inc.
This CE activity for ANCC and AANP credit is jointly provided by Global Education Group and Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by educational grants from Actelion Pharmaceuticals US, Inc., a Janssen Pharmaceutical Company of Johnson & Johnson and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

Pulmonary arterial hypertension (PAH) is the largest of the five subtypes, or groups as defined by the World Health Organization (WHO), that comprise pulmonary hypertension. An orphan disease with a poor prognosis, PAH presents in patients in the prime of their lives and affects women 3-5 times more often than men, inevitably causing right-heart failure and premature death, typically within 3-7 years.

Nurse practitioners (NPs) are uniquely situated to help ensure earlier diagnosis and treatment initiation for improved outcomes in patients with PAH. This program is therefore designed to provide critical education to NPs and other clinicians on the frontline of cardiopulmonary care to address these shortcomings in practice through improved knowledge and competence of strategies for earlier identification and diagnosis of PAH and implementation of effective treatment regimens.

TARGET AUDIENCE

This educational activity has been designed to meet the needs of nurse practitioners, advanced practice nurses, and physician assistants in primary care and specialty settings.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Delineate signs, symptoms, and risk factors that should raise the index of suspicion for PAH
• Identify patients who would benefit from referral to a cardiopulmonary specialist or PH/PAH specialty center to facilitate earlier diagnosis and treatment
• Design treatment plans that utilize current and emerging therapeutic regimens, including dual and triple combinations, and consider appropriate delivery mechanisms of individualized care of patients with PAH

FACULTY CHAIR

Martha Kingman, DNP, APRN, FNP-C Family Nurse Practitioner Pulmonary Hypertension Clinic University of Texas Southwestern Medical Center Dallas, Texas

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CE/CME activities:

Martha Kingman, DNP, APRN, FNP-C

Consultant/Advisor: Aerami, Aerovate, Bayer, Gossamer, Janssen, Liquidia, Merck, United Therapeutics

The Integrity Continuing Education, Inc. and the Global Education Group planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 30, 2023 through November 30, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 60% or better and a completed activity evaluation form.

ACCREDITATION

Physician Continuing Education

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nurse Practitioner Continuing Education

This activity has been planned and implemented in accordance with the Accreditation Standards of the American Association of Nurse Practitioners (AANP) through the joint providership of Global Education Group and Integrity Continuing Education. Global Education Group is accredited by the American Association of Nurse Practitioners as an approved provider of nurse practitioner continuing education. Provider number: 110121. This activity is approved for 1.0 contact hour (which includes 0.0 hour(s) of pharmacology).

Nursing Continuing Education

Global Education Group is accredited with distinction as a provider of nursing continuing professional development by the American Nurses Credentialing Center’s Commission on Accreditation.

This educational activity for 1.0 contact hour including 0.0 pharmacotherapeutic contact hour(s).  Nurses should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

For information about AANP or ANCC accreditation of this activity, please contact Global Education Group at (303) 395-1782 or cme@globaleducationgroup.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 27, 2023
Expiration date: November 27, 2024
Estimated time to complete activity: 45 minutes

PROVIDER STATEMENT

Provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

Supported by educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

This activity, Clinical Updates in Urothelial and Renal Cell Carcinoma from Madrid, features expert faculty Dr. Petros Grivas discussing the most important and clinically relevant data and framing it for integration into clinical practice. These insights are captured during the meeting and made available shortly thereafter to provide the latest information promptly for clinicians.

Abstracts included in the presentation include:

Urothelial Carcinoma

• LBA6 – EV-302/KEYNOTE-A39: Open-Label, Randomized Phase 3 Study of Enfortumab Vedotin in Combination with Pembrolizumab (EV+P) Vs Chemotherapy (Chemo) in Previously Untreated Locally Advanced Metastatic Urothelial Carcinoma (la/mUC)
• 2359O – Phase 3 THOR Study: Results of Erdafitinib (erda) vs Pembrolizumab (pembro) in Pretreated Patients (pts) With Advanced or Metastatic Urothelial Cancer (mUC) With Select Fibroblast Growth Factor Receptor Alterations (FGFRalt)
• LBA102 – THOR-2 cohort 1: Results of erdafitinib (ERDA) vs intravesical chemotherapy (chemo) in patients (pts) with high-risk non–muscle-invasive bladder cancer (HR NMIBC) with select fibroblast growth factor receptor alterations (FGFRALT) who received prior bacillus calmette-guérin (BCG) treatment
• LBA7 – Nivolumab plus gemcitabine-cisplatin versus gemcitabine-cisplatin alone for previously untreated unresectable or metastatic urothelial carcinoma: results from the phase 3 CheckMate 901 trial

Renal Cell Carcinoma

• LBA87 – Phase 2 LITESPARK-003 Study of Belzutifan in Combination With Cabozantinib for Advanced Clear Cell Renal Cell Carcinoma (ccRCC)
• LBA88 – Belzutifan versus everolimus in participants (pts) with previously treated advanced clear cell renal cell carcinoma (ccRCC): randomized open-label phase 3 LITESPARK-005 study
• 1881O – Safety and Efficacy of Two Doses of Belzutifan in Patients (pts) With Advanced RCC: Results of the Randomized Phase 2 LITESPARK-013 Study (Agarwal)

TARGET AUDIENCE

This educational activity was designed for community based medical oncologists and other healthcare providers that treat and manage patients with cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Compare and contrast new and emerging therapies with established treatment options
• Identify patients that could potentially benefit from referral to a clinical trial

FACULTY CHAIR

Petros Grivas, MD, PhD Professor, Department of Medicine Division of Hematology/Oncology Clinical Director, Genitourinary Cancers Program University of Washington Professor, Clinical Research Division Fred Hutchinson Cancer Center Seattle, Washington

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Petros Grivas, MD, PhD
Consulting: 4D Pharma PLC, Aadi Bioscience, AstraZeneca, Asieris Pharmaceuticals, Astellas Pharma, Bristol Myers Squibb, Boston Gene, CG Oncology, Dyania Health, Fresenius Kabi, G1 Therapeutics, Gilead, Guardant Health, ImmunityBio, Lucence Health, Infinity Pharmaceuticals, Janssen, Merck KGaA, MSD, Pfizer, PureTech, Roche, Seattle Genetics, Silverback Therapeutics, Strata Oncology, UroGen
Institutional research funding: Acrivon Therapeutics, ALX Oncology, Bavarian Nordic, Bristol Myers Squibb, Clovis Oncology, Debiopharm, G1 Therapeutics, Gilead, GlaxoSmithKline, Merck KGaA, MSD, Mirati Therapeutics, Pfizer, QED Therapeutics

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 27, 2023 through November 27, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 50% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 16, 2023
Expiration date: February 16, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

There is an obvious need for treatment options for cervical cancer that provide durable and meaningful improvements in survival – approximately half of the women (48%) who complete first-line (1L) therapy for cervical cancer in community-based care subsequently receive second-line therapy, with a median treatment-free interval of only 2.1 months. However, the treatment landscape is changing, and recent data has shown a survival benefit with the addition of immune checkpoint inhibitors to 1L chemotherapy, which may improve the outlook for many women with cervical cancer. This activity features a case-based discussion with expert faculty that will provide insight on the practical application of this new data.

In this Twitter-based Clinical Brief, Drs. Elenora Teplinsky and Gregg Nelson will discuss approaches to treatment and adverse event management for women with cervical cancer.

TARGET AUDIENCE

This educational activity was designed for medical and gynecologic oncologists who treat gynecologic malignancies.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Apply recommendations and clinical trial evidence to treatment and adverse event management for women with cervical cancer

FACULTY CHAIR

Eleonora Teplinsky, MD Head, Breast Medical Oncology Clinical Assistant Professor of Medicine Icahn School of Medicine at Mount Sinai Paramus, New Jersey

FACULTY DISCUSSANT

Gregg Nelson, MD, PhD, FRCSC Professor and Chief of Gynecologic Oncology Department of Obstetrics & Gynecology Cumming School of Medicine University of Calgary Calgary, Alberta

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Gregg Nelson, MD, PhD, FRCSC does not have any financial relationships or relationships to products or devices with ineligible companies.

Elenora Teplinsky, MD
Advisory Board: AstraZeneca
Medical Advisor: FloHealth, Sermo

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 16, 2023 through February 16, 2024 participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 8, 2023
Expiration date: November 8, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

The incidence of cervical cancer may be decreasing due to widespread screening and prevention efforts and improved access to care, but racial and ethnic disparities remain in both cervical cancer incidence and mortality, with higher rates among Black and Hispanic women than White women. Further, there is an obvious need for treatment options that provide durable and meaningful improvements in survival – approximately half of the women (48%) who complete first-line (1L) therapy for cervical cancer in community-based care subsequently receive second-line therapy, with a median treatment-free interval of only 2.1 months. However, the treatment landscape is changing, and recent data has shown a survival benefit with the addition of immune checkpoint inhibitors to 1L chemotherapy, which may improve the outlook for many women with cervical cancer.

This In the Clinic activity features a case-based discussion with expert faculty that will provide insight on the practical application of this new data.

TARGET AUDIENCE

This educational activity was designed for medical and gynecologic oncologists who treat gynecologic malignancies.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Apply recommendations and clinical trial evidence to treatment and adverse event management for women with cervical cancer
• Identify the effects of and strategies to overcome disparities in care

FACULTY

Martina C. Murphy, MD    Associate Professor of Medicine Program Director, Hematology/Oncology Fellowship University of Florida Assistant Director, Clinical Research Education & Professional Development Medical Director, Communication Strategies & Digital Innovation University of Florida Health Cancer Center Gainesville, Florida

CASE DEVELOPMENT FACULTY

Megan Hutchcraft, MD  Gynecologic Oncologist Carle Cancer Institute Assistant Clinical Professor Carle Illinois College of Medicine University of Illinois at Urbana-Champaign Champaign, Illinois

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Megan Hutchcraft, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

Martina C. Murphy, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 8, 2023 through November 8, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 66% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 15, 2023
Expiration date: March 15, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This program is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by an educational grant from GSK.

PROGRAM OVERVIEW

Anemia occurs in nearly all patients with myelofibrosis and is associated with poor prognosis, worse survival, and reduced quality of life. Patients with anemia will often require blood transfusion, though a subset will derive temporary benefit from androgens, corticosteroids, immunomodulators, or erythropoiesis stimulating agents. Since the majority of patients will not have a prolonged response to these agents, new therapies are needed and may soon enter clinical practice.

Treating and managing the complex etiology of myelofibrosis-associated anemia is challenging, especially for clinicians who practice outside of specialty/academic centers and do not regularly treat patients with myelofibrosis. This Twitter-based Clinical Brief activity will discuss emerging treatment options for patients with myelofibrosis.

TARGET AUDIENCE

This activity has been developed to meet the professional needs of medical oncologists and hematologists, as well as other healthcare professionals who treat and manage patients with hematologic malignancies.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Select the best treatment based on patient and disease characteristics

FACULTY CO-CHAIRS

	Luke Fletcher, MD Hematology/Oncologist Willamette Valley Cancer Institute Eugene, Oregon Clinical Researcher, Executive Committee Member Department of Malignant Hematology-Leukemia Sarah Cannon Research Institute Nashville, Tennessee
	Aaron T. Gerds, MD, MS Associate Professor of Medicine Hematology & Medical Oncology Deputy Director for Clinical Research Cleveland Clinic Taussig Cancer Institute Medical Director, Case Comprehensive Cancer Center Clinical Research Office Cleveland, Ohio

FACULTY DISCUSSANTS

	Andrew Kuykendall, MD Assistant Professor Oncologic Sciences University of South Florida Assistant Member, Moffit Cancer Center Department of Malignant Hematology Tampa, Florida
	Raajit Rampal, MD, PhD Director, Center for Hematologic Malignancies Director, Myeloproliferative Neoplasms Program Memorial Sloan Kettering Cancer Center New York, New York

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Luke Fletcher, MD
Consultant: Genzyme, Morphosys, Novartis, PharmaEssentia, Sanofi, Servier
Speaker: CTI Biopharma

Aaron T. Gerds, MD, MS
Consultant: AbbVie, Bristol Myers Squibb, CTI Biopharma, GSK/Sierra Oncology, Imago, Morphosys, Novartis, PharmaEssentia

Andrew Kyukendall, MD
Consultant: AbbVie, GSK
Honoraria: Bristol Myers Squibb, CTI Biopharma, Incyte, Morphosys
Research support: Bristol Myers Squibb, Janssen, Morphosys

Raajit Rampal, MD, PhD
Consultant: AbbVie, Blueprint, Bristol Myers Squibb, Cogent, Constellation, CTI Biopharma, Galecto, GSK, Incyte, Kartos, Karyopharm, Novartis, PharmaEssentia, Sumitomo Dainippon Pharma Oncology, Servier, Stemline, Zentalis

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 15, 2023 through March 15, 2024 participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 27, 2023
Expiration date: January 27, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

Provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

Supported by educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

International society meetings are a primary source of new data in oncology. Keeping up to date with the fast pace of oncology, sorting through thousands of abstracts, and deciding what is or is not ready for the clinic are daunting tasks. This activity, Clinical Updates in Urothelial Carcinoma from Madrid, features expert faculty Dr. Petros Grivas discussing the most important and clinically relevant data and framing it for integration into clinical practice. These insights are captured during the meeting and made available shortly thereafter to provide the latest information promptly for clinicians.

This Twitter-based activity will focus on first-line therapy for patients with locally advanced/metastatic urothelial carcinoma, irrespective of cisplatin eligibility.

TARGET AUDIENCE

This educational activity was designed for community based medical oncologists and other healthcare providers that treat and manage patients with cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Compare and contrast new and emerging therapies with established treatment options

FACULTY CHAIR

Petros Grivas, MD, PhD Professor, Department of Medicine Division of Hematology/Oncology Clinical Director, Genitourinary Cancers Program University of Washington Professor, Clinical Research Division Fred Hutchinson Cancer Center Seattle, WA

FACULTY DISCUSSANT

Jonathan Anker, MD, PhD Clinical and Research Fellow Department of Hematology and Medical Oncology The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai Hospital New York, New York

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Jonathan Anker, MD, PhD does not have any financial relationships or relationships to products or devices with ineligible companies.

Petros Grivas, MD, PhD
Consulting: 4D Pharma PLC, Aadi Bioscience, AstraZeneca, Asieris Pharmaceuticals, Astellas Pharma, Bristol Myers Squibb, Boston Gene, CG Oncology, Dyania Health, Fresenius Kabi, G1 Therapeutics, Gilead, Guardant Health, ImmunityBio, Lucence Health, Infinity Pharmaceuticals, Janssen, Merck KGaA, MSD, Pfizer, PureTech, Roche, Seattle Genetics, Silverback Therapeutics, Strata Oncology, UroGen
Institutional research funding: Acrivon Therapeutics, ALX Oncology, Bavarian Nordic, Bristol Myers Squibb, Clovis Oncology, Debiopharm, G1 Therapeutics, Gilead, GlaxoSmithKline, Merck KGaA, MSD, Mirati Therapeutics, Pfizer, QED Therapeutics

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 27, 2023 through January 27, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 50% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 2, 2023
Expiration date: February 2, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

Provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

Supported by educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

International society meetings are a primary source of new data in oncology. Keeping up to date with the fast pace of oncology, sorting through thousands of abstracts, and deciding what is or is not ready for the clinic are daunting tasks. This activity, Clinical Updates in Breast Cancer from Madrid, features expert faculty Dr. Aditya Bardia discussing the most important and clinically relevant data and framing it for integration into clinical practice. These insights are captured during the meeting and made available shortly thereafter to provide the latest information promptly for clinicians.

This Twitter-based activity will focus on neoadjuvant immune checkpoint inhibitor + chemotherapy for high-risk ER+/HER2- breast cancer.

TARGET AUDIENCE

This educational activity was designed for community based medical oncologists and other healthcare providers that treat and manage patients with cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Compare and contrast new and emerging therapies with established treatment options

FACULTY CHAIR

Aditya Bardia, MD Director, Breast Cancer Research Associate Professor Harvard Medical School Attending Physician Massachusetts General Hospital Boston, Massachusetts

FACULTY DISCUSSANT

Megan Tesch, MD Instructor in Medicine Harvard Medical School Physician Dana-Farber Cancer Institute Breast Oncology Center Boston, Massachusetts

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Aditya Bardia, MD
Consultant: AstraZeneca, Daiichi Sankyo, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, Pfizer, Sanofi
Research Grants: AstraZeneca, Daiichi Sankyo, Eli Lilly, Genentech, Gilead, Menarini, Merck, Novartis, Pfizer, Sanofi

Megan Tesch, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 2, 2023 through February 2, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 50% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 9, 2023
Expiration date: February 9, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from Incyte Corporation.

PROGRAM OVERVIEW

“If you’ve seen one patient with vitiligo…you’ve seen one patient with vitiligo,” vitiligo expert Dr. David Rosmarin is fond of saying. This relatively common dermatologic disorder can present in a wide variety of ways and its impact on patients’ quality of life can be profound yet highly individual.

In this Twitter-based Clinical Brief, David Rosmarin, MD, Colleen Cotton, MD, FAAD, and Seemal Desai, MD, FAAD will discuss switching therapies to align with patients’ vitiligo treatment goals.

TARGET AUDIENCE

This educational activity has been designed to meet the needs of dermatologists, family practice physicians, nurse practitioners, physician assistants, and other clinicians who manage patients with vitiligo.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Recall clinical trial data for new and emerging therapies for vitiligo

FACULTY CHAIR

David Rosmarin, MD Chair of Dermatology Kampen-Norins Scholar Indiana University School of Medicine Indianapolis, Indiana

FACULTY DISCUSSANTS

	Colleen Cotton, MD, FAAD Assistant Professor of Dermatology and Pediatrics George Washington School of Medicine and Health Sciences Attending Physician Division of Dermatology, Children’s National Hospital Washington, District of Columbia
	Seemal Desai, MD, FAAD Founder and Medical Director Innovative Dermatology Clinical Assistant Professor Department of Dermatology The University of Texas Southwestern Dallas, Texas

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Colleen Cotton, MD, FAAD
Advisor: Avita, Bristol Myers Squibb, Janssen Biotech, LEO Pharma
Consultant: Pierre Fabre
Salary Support: Eli Lilly, Regeneron, Target RWA
Research: AbbVie, Arcutis Biotherapeutics

Seemal Desai, MD, FAAD
Advisory Board: Foundation for Research & Education of Dermatology
Board of Directors: Global Vitiligo Foundation, International Society of Dermatology, Women’s Derm Society
Consultant: AbbVie, Allergan, Inc., Almirall, Amgen, Apogee Therapeutics, Avita, Ballature Beauty, Beiersdorf, Inc., Bristol Myers Squibb, Candela Corporation, Cassiopea S.p.A., Castle Biosciences, Cutera, Inc., Dermavant Sciences, Dermira, Eli Lilly and Company, EPI Health, Ferndale Laboratories, Inc., Foamix, Galderma Laboratories, LP, Gore Range Capital, Hyphens Pharma, Incyte Corporation, Janssen Pharmaceuticals, Inc., Johnson and Johnson, Leo Pharma Inc., L’Oreal USA Inc., Lyceum Health, Ortho Dermatologics, Pfizer Inc., Revision Skincare, Sanofi/Regeneron, Scientis, Skin Science Advisors, UCB, Verrica Pharmaceuticals Inc., VYNE Therapeutics
Investigator: AOBiome, LLC., Atacama Therapeutics, Dermavant Sciences, Incyte Corporation, SkinMedica, Inc.
Other: Medscape, National Psoriasis Foundation, PDH Holdings LLC
Founder: Illuminate Skin Care LLC
Speaker: AbbVie, Dermira, Galderma Laboratories, LP., Pfizer Inc.
Stockholder: Gore Range Capital

David Rosmarin, MD
Consultant: AbbVie, Abcuro, AltruBio, Arena, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Concert, CSL Behring, Dermavant, Dermira, Incyte, Janssen, Kyowa Kirin, Lilly, Novartis, Pfizer, Recludix, Regeneron, Revolo Biotherapeutics, Sanofi, Sun Pharma, UCB, Viela Bio
Research: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermira, Galderma, Incyte, Janssen, Lilly, Merck, Novartis, Pfizer, Regeneron
Speaker: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermavant, Incyte, Janssen, Lilly, Novartis, Pfizer, Regeneron, Sanofi

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 9, 2023 through February 9, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 1, 2023
Expiration date: February 1, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

Provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

Supported by educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

International society meetings are a primary source of new data in oncology. Keeping up to date with the fast pace of oncology, sorting through thousands of abstracts, and deciding what is or is not ready for the clinic are daunting tasks. This activity, Clinical Updates in Non-Small Cell Lung Cancer from Madrid, features expert faculty Dr. Ticiana Leal discussing the most important and clinically relevant data and framing it for integration into clinical practice. These insights are captured during the meeting and made available shortly thereafter to provide the latest information promptly for clinicians.

This Twitter-based activity will focus on the new first-line standard of care for epidermal growth factor receptor (EGFR) exon 20 insertion-mutated advanced non-small cell lung cancer.

TARGET AUDIENCE

This educational activity was designed for community based medical oncologists and other healthcare providers that treat and manage patients with cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Compare and contrast new and emerging therapies with established treatment options

FACULTY CHAIR

Ticiana Leal, MD Associate Professor Department of Hematology/Oncology Director, Thoracic Medical Oncology Program Winship Cancer Institute Emory University Atlanta, Georgia

FACULTY DISCUSSANT

Aakash Desai, MD, MPH Assistant Professor University of Alabama at Birmingham Birmingham, Alabama

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Ticiana Leal, MD
Advisory board: AstraZeneca, Bayer, BeyondSpring, Blueprint, Boehringer Ingelheim, Bristol Myers Squibb, EMD Serono, Genentech, InvisionFirst Lung, Janssen, Jazz, Merck, Takeda
Consultant: AstraZeneca, Boehringer Ingelheim, Genentech, Janssen, Jazz, Lilly

Aakash Desai, MD, MPH
Consultant: Amgen, AstraZeneca, Foundation Medicine, Sanofi

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 1, 2023 through February 1, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 50% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: November 1, 2023
Expiration date: March 1, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This program is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by an educational grant from GSK.

PROGRAM OVERVIEW

Anemia occurs in nearly all patients with myelofibrosis and is associated with poor prognosis, worse survival, and reduced quality of life. Patients with anemia will often require blood transfusion, though a subset will derive temporary benefit from androgens, corticosteroids, immunomodulators, or erythropoiesis stimulating agents. Since the majority of patients will not have a prolonged response to these agents, new therapies are needed and may soon enter clinical practice.

Treating and managing the complex etiology of myelofibrosis-associated anemia is challenging, especially for clinicians who practice outside of specialty/academic centers and do not regularly treat patients with myelofibrosis. This Twitter-based Clinical Brief activity will discuss the unmet needs in patients with myelofibrosis, with a focus on prognostic factors and how they impact treatment choices.

TARGET AUDIENCE

This activity has been developed to meet the professional needs of medical oncologists and hematologists, as well as other healthcare professionals who treat and manage patients with hematologic malignancies.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Assess and apply prognostic scoring in the treatment planning process

FACULTY CO-CHAIRS

	Luke Fletcher, MD Hematology/Oncologist Willamette Valley Cancer Institute Eugene, Oregon Clinical Researcher, Executive Committee Member Department of Malignant Hematology-Leukemia Sarah Cannon Research Institute Nashville, Tennessee
	Aaron T. Gerds, MD, MS Associate Professor of Medicine Hematology & Medical Oncology Deputy Director for Clinical Research Cleveland Clinic Taussig Cancer Institute Medical Director, Case Comprehensive Cancer Center Clinical Research Office Cleveland, Ohio

FACULTY DISCUSSANTS

	Talha Badar, MD, MBBS Department of Hematology and Oncology Mayo Clinic Jacksonville, Florida
	Vikas Gupta, MD, FRCP, FRCPath Professor, Department of Medicine Department of Medical Oncology and Hematology University of Toronto Site Group Lead, Leukemia/MPN Programs Princess Margaret Cancer Centre Ontario, Canada

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Talha Badar, MD, MBBS
Advisory Boards: Pfizer, Takeda

Luke Fletcher, MD
Consultant: Genzyme, Morphosys, Novartis, PharmaEssentia, Sanofi, Servier
Speaker: CTI Biopharma

Aaron T. Gerds, MD, MS
Consultant: AbbVie, Bristol Myers Squibb/Celgene, CTI Biopharma, GSK/Sierra Oncology, Imago, Morphosys, Novartis, PharmaEssentia

Vikas Gupta, MD, FRCP, FRCPath
Consultant: AbbVie, Bristol Myers Squibb/Celgene, CTI Biopharma, Incyte, Morphosys, Novartis, Sierra Oncology, Takeda
Research Support: Novartis
Scientific Advisory Board: AbbVie, Bristol Myers Squibb/Celgene, CTI Biopharma, Incyte, Morphosys, Novartis, Sierra Oncology, Takeda

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of November 1, 2023 through March 1, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 31, 2023
Expiration date: April 30, 2024
Estimated time to complete activity: 45 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc., and Sanofi.

PROGRAM OVERVIEW

Chronic rhinosinusitis (CRS) is among the most prevalent and expensive chronic disorders in the US. According to the Centers for Disease Control and Prevention, 28.9 million adults (11.6%) have CRS, and at least one economic analysis ranks the disease among the top 10 most costly conditions. Among patients with CRS, an estimated 25%–30% have concurrent nasal polyps (CRSwNP). CRSwNP is most commonly observed in patients between 40 and 60 years of age, and while polyps are more common in men, women are more likely to have severe disease, comorbid asthma, and aspirin-exacerbated respiratory disease. Compared to their counterparts without polyps (CRSsNP), patients with CRSwNP carry a much higher disease burden, greater risk for comorbidities, the need for functional endoscopic sinus surgery (ESS), repeat revision surgeries, and dependence on oral corticosteroids (OCS).

This activity will improve patient care through improved ability to assess disease severity and burden, selection of patients for surgical or biologic treatment options, and evidence on comparative safety and efficacy and real-world data of available treatments for CRSwNP. Listen in as Drs. Lee, Peters, and Platt present a brief lecture, then participate in an interactive poster session where they dive deeper into these topics.

TARGET AUDIENCE

This activity addresses the needs of otolaryngic allergists, physicians, physician assistants, and nurse practitioners involved in the management of patients with CRSwNP.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Apply evidence-based guidance to assess the severity and QOL impact of CRSwNP
• Evaluate clinical trial data on the efficacy and safety of biologics and surgical options for patients with CRSwNP
• Incorporate current guidelines and expert recommendations into the positioning of biologic therapy, sinus surgery, and OCS for the treatment of patients with CRSwNP

FACULTY

	Stella Lee, MD Section Chief Rhinology Brigham and Women’s Hospital Harvard Medical School Weston, Massachusetts
	Anju T. Peters, MD Professor of Medicine Director of Clinical Research Division of Allergy/Immunology and Otolaryngology Northwestern University Feinberg School of Medicine Chicago, Illinois
	Michael Platt, MD, MSc Associate Professor and Residency Director Director of Rhinology and Endoscopic Skull Base Surgery Department of Otolaryngology- Head and Neck Surgery Chobanian and Avedesian School of Medicine Boston University Boston, Massachusetts

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Stella Lee, MD
Advisory Board: AstraZeneca, Genentech, GSK, Lyra Therapeutics, OptiNose, Sanofi Regeneron

Anju Peters, MD
Advisory Board: AstraZeneca, GSK, Merck, Sanofi Regeneron
Consulting: OptiNose
Research: AstraZeneca, Merck, Sanofi Regeneron

Michael Platt, MD, MSc
Consulting: GI Reviewers, LLC. Independent reader for CRS biologics studies

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 31, 2023 through April 30, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 75% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 30, 2023
Expiration date: January 30, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

Provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

Supported by educational grants from Janssen Biotech, Inc., administered by Janssen Scientific Affairs, LLC and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

International society meetings are a primary source of new data in oncology. Keeping up to date with the fast pace of oncology, sorting through thousands of abstracts, and deciding what is or is not ready for the clinic are daunting tasks. This activity, Clinical Updates in Renal Cell Carcinoma from Madrid, features expert faculty Dr. Petros Grivas discussing the most important and clinically relevant data and framing it for integration into clinical practice. These insights are captured during the meeting and made available shortly thereafter to provide the latest information promptly for clinicians.

This Twitter-based activity will focus on post-immunotherapy tyrosine kinase inhibitor (TKI) therapy in renal cell carcinoma.

TARGET AUDIENCE

This educational activity was designed for community based medical oncologists and other healthcare providers that treat and manage patients with cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Compare and contrast new and emerging therapies with established treatment options

FACULTY CHAIR

Petros Grivas, MD, PhD Professor, Department of Medicine Division of Hematology/Oncology Clinical Director, Genitourinary Cancers Program University of Washington Professor, Clinical Research Division Fred Hutchinson Cancer Center Seattle, Washington

FACULTY DISCUSSANT

Jonathan Anker, MD, PhD Clinical and Research Fellow Department of Hematology and Medical Oncology The Tisch Cancer Institute Icahn School of Medicine at Mount Sinai Hospital New York, New York

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Jonathan Anker, MD, PhD does not have any financial relationships or relationships to products or devices with ineligible companies.

Petros Grivas, MD, PhD
Consulting: 4D Pharma PLC, Aadi Bioscience, AstraZeneca, Asieris Pharmaceuticals, Astellas Pharma, Bristol Myers Squibb, Boston Gene, CG Oncology, Dyania Health, Fresenius Kabi, G1 Therapeutics, Gilead, Guardant Health, ImmunityBio, Lucence Health, Infinity Pharmaceuticals, Janssen, Merck KGaA, MSD, Pfizer, PureTech, Roche, Seattle Genetics, Silverback Therapeutics, Strata Oncology, UroGen
Institutional research funding: Acrivon Therapeutics, ALX Oncology, Bavarian Nordic, Bristol Myers Squibb, Clovis Oncology, Debiopharm, G1 Therapeutics, Gilead, GlaxoSmithKline, Merck KGaA, MSD, Mirati Therapeutics, Pfizer, QED Therapeutics

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 30, 2023 through January 30, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 50% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: September 29, 2023
Expiration date: March 29, 2024
Estimated time to complete activity: 30 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc.

PROGRAM OVERVIEW

Homozygous familial hypercholesterolemia (HoFH) is a genetic disorder characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-C), leading to premature cardiovascular disease. Affected individuals are typically less responsive or unresponsive to standard lipid-lowering therapies (ie, statins and PCSK9 inhibitors) and may benefit from treatments with alternative mechanisms of action, such as the recently FDA-approved ANGPTL3 inhibitor evinacumab. With this in mind, this program has been designed to educate clinicians about the prevalence of HoFH, the importance of HoFH screening, and the benefits and limitations of current therapies for lipid management in patients with the disease. The nationally-recognized expert faculty in HoFH presenting this activity will provide practical advice geared for an audience of primary care providers regarding the best strategies to improve patient access to newer lipid-lowering therapies.

TARGET AUDIENCE

This educational activity has been designed for US internal medicine physicians, nurse practitioners, and physician assistants involved in the identification, diagnosis, and management of patients with HoFH.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Contrast the estimated prevalence versus the number of patients diagnosed with familial hypercholesterolemia (FH)
• Apply knowledge of cardinal symptoms and strategies for early identification of HoFH
• Employ cascade screening to ensure case identification in first degree relatives of patients with HoFH
• Discuss the role of low-density lipoprotein receptor-independent treatment strategies for patients with HoFH

FACULTY

Mary P. McGowan, MD Assistant Professor of Medicine Geisel School of Medicine at Dartmouth Co-Director, Lipid Clinic Dartmouth Hitchcock Medical Center Lebanon, New Hampshire

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Mary P. McGowan, MD
Consultant: Novartis
Speaker: Abbott

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of September 29, 2023 through March 29, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 70% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 26, 2023
Expiration date: January 26, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from Incyte Corporation.

PROGRAM OVERVIEW

“If you’ve seen one patient with vitiligo…you’ve seen one patient with vitiligo,” vitiligo expert Dr. David Rosmarin is fond of saying. This relatively common dermatologic disorder can present in a wide variety of ways and its impact on patients’ quality of life can be profound yet highly individual.

In this Twitter-based Clinical Brief, David Rosmarin, MD, Colleen Cotton, MD, FAAD, and Seemal Desai, MD, FAAD will discuss therapy options available to younger patients who have been diagnosed with vitiligo.

TARGET AUDIENCE

This educational activity has been designed to meet the needs of dermatologists, family practice physicians, nurse practitioners, physician assistants, and other clinicians who manage patients with vitiligo.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Recall clinical trial data for new and emerging therapies for vitiligo

FACULTY CHAIR

David Rosmarin, MD Chair of Dermatology Kampen-Norins Scholar Indiana University School of Medicine Indianapolis, Indiana

FACULTY DISCUSSANTS

	Colleen Cotton, MD, FAAD Assistant Professor of Dermatology and Pediatrics George Washington School of Medicine and Health Sciences Attending Physician Division of Dermatology, Children’s National Hospital Washington, District of Columbia
	Seemal Desai, MD, FAAD Founder and Medical Director Innovative Dermatology Clinical Assistant Professor Department of Dermatology The University of Texas Southwestern Dallas, Texas

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Colleen Cotton, MD, FAAD
Advisor: Avita, Bristol Myers Squibb, Janssen Biotech, LEO Pharma
Consultant: Pierre Fabre
Salary Support: Eli Lilly, Regeneron, Target RWA
Research: AbbVie, Arcutis Biotherapeutics

Seemal Desai, MD, FAAD
Advisory Board: Foundation for Research & Education of Dermatology
Board of Directors: Global Vitiligo Foundation, International Society of Dermatology, Women’s Derm Society
Consultant: AbbVie, Allergan, Inc., Almirall, Amgen, Apogee Therapeutics, Avita, Ballature Beauty, Beiersdorf, Inc., Bristol Myers Squibb, Candela Corporation, Cassiopea S.p.A., Castle Biosciences, Cutera, Inc., Dermavant Sciences, Dermira, Eli Lilly and Company, EPI Health, Ferndale Laboratories, Inc., Foamix, Galderma Laboratories, LP, Gore Range Capital, Hyphens Pharma, Incyte Corporation, Janssen Pharmaceuticals, Inc., Johnson and Johnson, Leo Pharma Inc., L’Oreal USA Inc., Lyceum Health, Ortho Dermatologics, Pfizer Inc., Revision Skincare, Sanofi/Regeneron, Scientis, Skin Science Advisors, UCB, Verrica Pharmaceuticals Inc., VYNE Therapeutics
Investigator: AOBiome, LLC., Atacama Therapeutics, Dermavant Sciences, Incyte Corporation, SkinMedica, Inc.
Other: Medscape, National Psoriasis Foundation, PDH Holdings LLC
Founder: Illuminate Skin Care LLC
Speaker: AbbVie, Dermira, Galderma Laboratories, LP., Pfizer Inc.
Stockholder: Gore Range Capital

David Rosmarin, MD
Consultant: AbbVie, Abcuro, AltruBio, Arena, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Concert, CSL Behring, Dermavant, Dermira, Incyte, Janssen, Kyowa Kirin, Lilly, Novartis, Pfizer, Recludix, Regeneron, Revolo Biotherapeutics, Sanofi, Sun Pharma, UCB, Viela Bio
Research: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermira, Galderma, Incyte, Janssen, Lilly, Merck, Novartis, Pfizer, Regeneron
Speaker: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermavant, Incyte, Janssen, Lilly, Novartis, Pfizer, Regeneron, Sanofi

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 26, 2023 through January 26, 2023, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 25, 2023
Expiration date: January 25, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

The incidence of cervical cancer may be decreasing due to widespread screening and prevention efforts and improved access to care, but racial and ethnic disparities remain in both cervical cancer incidence and mortality, with higher rates among Black and Hispanic women than White women.

In this Twitter-based Clinical Brief, Drs. Martina C. Murphy and Bhavana Pothuri will discuss the disparities among Black and Hispanic women versus White women, ways to reduce these disparities, and the importance of inclusive clinical trial participation.

TARGET AUDIENCE

This educational activity was designed for medical and gynecologic oncologists who treat gynecologic malignancies.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Identify the effects of and strategies to overcome disparities in care

FACULTY CHAIR

Bhavana Pothuri, MD, MS Professor, Department of Obstetrics and Gynecology Division of Gynecologic Oncology Grossman School of Medicine New York University Gynecologic Oncologist NYU Langone Health New York, New York

FACULTY DISCUSSANT

Martina C. Murphy, MD Associate Professor of Medicine Program Director, Hematology/Oncology Fellowship University of Florida Assistant Director, Clinical Research Education & Professional Development Medical Director, Communication Strategies & Digital Innovation University of Florida Health Cancer Center Gainesville, Florida

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Martina Murphy, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

Bhavana Pothuri, MD, MS
Consulting Fees: AstraZeneca, Celsion, Curio Science, Eisai, GOG Foundation, Imvax Inc, Immunogen, Incyte, Inxmed, Lilly, Merck, Regeneron, R Pharm, Seattle Genetics, Signatera, Sutro Biopharma, Tesaro/GSK
Executive Role: GOG Partners, NYOB Society Treasurer, SGO Board of Directors, SGO Clinical Practice Committee Chair, SGO COVID-19 Taskforce Co-Chair
Grant/Research Funding: Acrivon, Agenus, AstraZeneca, Celgene, Celsion/Immunon, Clovis Oncology, Eisai, Imab, Immunogen, Incyte, Inxmed, Merck, Mersana, Novocure, NRG Oncology, Onconova, Roche/Genentech, Seagen, Sutro Biopharma, Takeda, Tesaro/GSK, Toray, VBL Therapeutics, Xencor
Honoraria: Bioascend, OncLive PERS, PeerView, Vanium, WebMD, Yale University

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 25, 2023 through January 25, 2024 participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 23, 2023
Expiration date: October 23, 2024
Estimated time to complete activity: 45 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an educational grant from Incyte Corporation.

PROGRAM OVERVIEW

“If you’ve seen one patient with vitiligo…you’ve seen one patient with vitiligo,” vitiligo expert Dr. David Rosmarin is fond of saying. This relatively common dermatologic disorder can present in a wide variety of ways and its impact on patients’ quality of life can be profound yet highly individual. As the pathogenesis of vitiligo began to reveal itself, it became clear that this autoimmune inflammatory disease is medical, not cosmetic, and can be managed by blocking aberrant signaling through the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. However, until July 2022, there was no FDA-approved treatment that could accomplish this and restore the pigment lost to the destruction of melanocytes on the face, hands, or anywhere on the body. There is now a new treatment, ruxolitinib cream 1.5%, approved for use by adolescents and adults with nonsegmental vitiligo of any severity and in all parts of the body.

Join Dr. Rosmarin as he presents information about this and other emerging JAK inhibitors and offers ideas and treatment recommendations for case study patients that are likely to resemble, but not replicate, your highly individual vitiligo patients.

TARGET AUDIENCE

This educational activity has been designed to meet the needs of dermatologists, family practice physicians, nurse practitioners, physician assistants, and other clinicians who manage patients with vitiligo.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Improve clinicians’ knowledge of the pathogenesis of vitiligo
• Describe the role of the JAK/STAT pathway in vitiligo
• Recall clinical trial data for new and emerging therapies for vitiligo

FACULTY

David Rosmarin, MD Chair of Dermatology Kampen-Norins Scholar Indiana University School of Medicine Indianapolis, Indiana

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

David Rosmarin, MD
Consultant: AbbVie, Abcuro, AltruBio, Arena, Boehringer Ingelheim, Bristol Myers Squibb, Celgene, Concert, CSL Behring, Dermavant, Dermira, Incyte, Janssen, Kyowa Kirin, Lilly, Novartis, Pfizer, Recludix, Regeneron, Revolo Biotherapeutics, Sanofi, Sun Pharma, UCB, Viela Bio
Research: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermira, Galderma, Incyte, Janssen, Lilly, Merck, Novartis, Pfizer, Regeneron
Speaker: AbbVie, Amgen, Bristol Myers Squibb, Celgene, Dermavant, Incyte, Janssen, Lilly, Novartis, Pfizer, Regeneron, Sanofi

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 23, 2023 through October 23, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 55% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: September 1, 2023
Expiration date: December 31, 2023
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi.

PROGRAM OVERVIEW

Treatment with biologic therapy as compared with maintenance corticosteroids (oral or high-dose inhaled) has consistently been shown to reduce disease burden among a wide range of individuals with moderate-to-severe asthma. Nevertheless, a significant subset of patients treated with biologics continue to experience poor asthma control and a high burden of disease, raising important questions regarding how to optimize the use of available therapies. Join our esteemed clinician faculty as they discuss long-term biologic treatment data for patients with moderate-to-severe asthma.

TARGET AUDIENCE

This educational activity has been designed for US allergists, pulmonologists, advanced practice providers in allergy and pulmonary settings, and internal medicine clinicians.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Review long-term efficacy and safety data of available biologics reported in real-world and open-label extension trials

FACULTY CO-CHAIRS

	Linda B. Ford, MD, FAAAAI, FACAAI, AE-C Clinical Assistant Professor Department of Pediatrics University of Nebraska Medical Center President and CEO The Asthma & Allergy Center, PC Omaha, Nebraska
	Reynold A. Panettieri, Jr., MD Vice Chancellor, Translational Medicine and Science Director, Rutgers Institute for Translational Medicine and Science Professor of Medicine, Rutgers University Emeritus Professor of Medicine, University of Pennsylvania New Brunswick, New Jersey

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Linda B. Ford, MD, FAAAAI, FACAAI, AE-C
Independent Contractor: Allergy Therapeutics, AstraZeneca, Bellus, Chiesi, Enanta, Genentech, Koneksa, Regeneron, Sanofi, Suzhou

Reynold A. Panettieri, Jr., MD
Advisor: Praesidia Biotherapies Inc.
Advisory Board: AstraZeneca, Genentech, RIFM
Consultant: AstraZeneca, RIFM, TEVA
Research Grants: ACTIV-1, AgoMab, AstraZeneca, Janssen, Medimmune, RIFM, TEVA, Vault Health
Speaker: AstraZeneca, Merck & Co., Sanofi

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of September 1, 2023 through December 31, 2023, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: September 1, 2023
Expiration date: December 31, 2023
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi.

PROGRAM OVERVIEW

Treatment with biologic therapy as compared with maintenance corticosteroids (oral or high-dose inhaled) has consistently been shown to reduce disease burden among a wide range of individuals with moderate-to-severe asthma. Nevertheless, a significant subset of patients treated with biologics continue to experience poor asthma control and a high burden of disease, raising important questions regarding how to optimize the use of available therapies. Join our esteemed clinician faculty as they discuss evaluating biologic therapy responses for patients with moderate-to-severe asthma to improve health outcomes.

TARGET AUDIENCE

This educational activity has been designed for US allergists, pulmonologists, advanced practice providers in allergy and pulmonary settings, and internal medicine clinicians.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Describe current recommendations for assessment of biologic therapy after initiation and factors that may predispose patients to biologic stopping or switching in the first year of therapy

FACULTY CO-CHAIRS

	Linda B. Ford, MD, FAAAAI, FACAAI, AE-C Clinical Assistant Professor Department of Pediatrics University of Nebraska Medical Center President and CEO The Asthma & Allergy Center, PC Omaha, Nebraska
	Reynold A. Panettieri, Jr., MD Vice Chancellor, Translational Medicine and Science Director, Rutgers Institute for Translational Medicine and Science Professor of Medicine, Rutgers University Emeritus Professor of Medicine, University of Pennsylvania New Brunswick, New Jersey

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Linda B. Ford, MD, FAAAAI, FACAAI, AE-C
Independent Contractor: Allergy Therapeutics, AstraZeneca, Bellus, Chiesi, Enanta, Genentech, Koneksa, Regeneron, Sanofi, Suzhou

Reynold A. Panettieri, Jr., MD
Advisor: Praesidia Biotherapies Inc.
Advisory Board: AstraZeneca, Genentech, RIFM
Consultant: AstraZeneca, RIFM, TEVA
Research Grants: ACTIV-1, AgoMab, AstraZeneca, Janssen, Medimmune, RIFM, TEVA, Vault Health
Speaker: AstraZeneca, Merck & Co., Sanofi

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of September 1, 2023 through December 31, 2023, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: September 1, 2023
Expiration date: December 31, 2023
Estimated time to complete activity: 30 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi.

PROGRAM OVERVIEW

Treatment with biologic therapy as compared with maintenance corticosteroids (oral or high-dose inhaled) has consistently been shown to reduce disease burden among a wide range of individuals with moderate-to-severe asthma. Nevertheless, a significant subset of patients treated with biologics continues to experience poor asthma control and a high burden of disease, raising important questions regarding how to optimize the use of available therapies. Join our esteemed clinician faculty as they discuss the selection of appropriate initial biologic therapy for patients with moderate-to-severe asthma to improve health outcomes.

TARGET AUDIENCE

This educational activity has been designed for US allergists, pulmonologists, advanced practice providers in allergy and pulmonary settings, and internal medicine clinicians.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Select the most appropriate biologic for patients with uncontrolled asthma based on comprehensive assessment of individual characteristics

FACULTY CO-CHAIRS

	Linda B. Ford, MD, FAAAAI, FACAAI, AE-C Clinical Assistant Professor Department of Pediatrics University of Nebraska Medical Center President and CEO The Asthma & Allergy Center, PC Omaha, Nebraska
	Reynold A. Panettieri, Jr., MD Vice Chancellor, Translational Medicine and Science Director, Rutgers Institute for Translational Medicine and Science Professor of Medicine, Rutgers University Emeritus Professor of Medicine, University of Pennsylvania New Brunswick, New Jersey

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Linda B. Ford, MD, FAAAAI, FACAAI, AE-C
Independent Contractor: Allergy Therapeutics, AstraZeneca, Bellus, Chiesi, Enanta, Genentech, Koneksa, Regeneron, Sanofi, Suzhou

Reynold A. Panettieri, Jr., MD
Advisor: Praesidia Biotherapies Inc.
Advisory Board: AstraZeneca, Genentech, RIFM
Consultant: AstraZeneca, RIFM, TEVA
Research Grants: ACTIV-1, AgoMab, AstraZeneca, Janssen, Medimmune, RIFM, TEVA, Vault Health
Speaker: AstraZeneca, Merck & Co., Sanofi

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of September 1, 2023 through December 31, 2023, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 25, 2023
Expiration date: October 25, 2024
Estimated time to complete activity: 45 minutes

PROVIDER STATEMENT

This program is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by an educational grant from GlaxoSmithKline LLC.

PROGRAM OVERVIEW

Anemia occurs in nearly all patients with myelofibrosis and is associated with poor prognosis, worse survival, and reduced quality of life. Patients with anemia will often require blood transfusion, though a subset will derive temporary benefit from androgens, corticosteroids, immunomodulators, or erythropoiesis stimulating agents. Since the majority of patients will not have a prolonged response to these agents, new therapies are needed and may soon enter clinical practice.

Treating and managing the complex etiology of myelofibrosis-associated anemia is challenging, especially for clinicians who practice outside of specialty/academic centers and do not regularly treat patients with myelofibrosis.

This interactive, on-demand program features a clinical case and allows you to assess the patient and select treatment. Insight and guidance on the case and treatment approach are provided by two expert faculty in video discussions.

TARGET AUDIENCE

This activity has been designed to meet the professional needs of medical oncologists and hematologists, as well as other healthcare professionals who treat and manage patients with hematologic malignancies.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Assess and apply prognostic scoring in the treatment planning process
• Select the best treatment based on patient and disease characteristics

FACULTY

	Luke Fletcher, MD Hematology/Oncologist Willamette Valley Cancer Institute Eugene, Oregon Clinical Researcher, Executive Committee Member Department of Malignant Hematology-Leukemia Sarah Cannon Research Institute Nashville, Tennessee
	Aaron T. Gerds, MD, MS Associate Professor of Medicine Hematology & Medical Oncology Deputy Director for Clinical Research Cleveland Clinic Taussig Cancer Institute Medical Director, Case Comprehensive Cancer Center Clinical Research Office Cleveland, Ohio

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Luke Fletcher, MD
Consultant: Genzyme, Morphosys, Novartis, Pharmaessentia, Sanofi, Servier
Speaker: CTI Biopharma

Aaron T. Gerds, MD, MS
Consultant: AbbVie, Bristol Myers Squibb, CTI Biopharma, GlaxoSmithKline/Sierra Oncology, Imago, Morphosys, Novartis, PharmaEssentia

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 25, 2023 through October 25, 2024 participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 66% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 18, 2023
Expiration date: January 18, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This program is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by an educational grant from GSK.

PROGRAM OVERVIEW

Anemia occurs in nearly all patients with myelofibrosis and is associated with poor prognosis, worse survival, and reduced quality of life. Patients with anemia will often require blood transfusion, though a subset will derive temporary benefit from androgens, corticosteroids, immunomodulators, or erythropoiesis stimulating agents. Since the majority of patients will not have a prolonged response to these agents, new therapies are needed and may soon enter clinical practice.

Treating and managing the complex etiology of myelofibrosis-associated anemia is challenging, especially for clinicians who practice outside of specialty/academic centers and do not regularly treat patients with myelofibrosis. This Twitter-based Clinical Brief activity will discuss the unmet needs in patients with myelofibrosis, with a focus on anemia and transfusion-dependency.

TARGET AUDIENCE

This activity has been developed to meet the professional needs of medical oncologists and hematologists, as well as other healthcare professionals who treat and manage patients with hematologic malignancies.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Select the best treatment based on patient and disease characteristics

FACULTY CO-CHAIRS

	Luke Fletcher, MD Hematology/Oncologist Willamette Valley Cancer Institute Eugene, Oregon Clinical Researcher, Executive Committee Member Department of Malignant Hematology-Leukemia Sarah Cannon Research Institute Nashville, Tennessee
	Aaron T. Gerds, MD, MS Associate Professor of Medicine Hematology & Medical Oncology Deputy Director for Clinical Research Cleveland Clinic Taussig Cancer Institute Medical Director, Case Comprehensive Cancer Center Clinical Research Office Cleveland, Ohio

FACULTY DISCUSSANTS

	Tania Jain, MBBS Assistant Professor Department of Oncology Johns Hopkins University Baltimore, Maryland
	Andrew Kuykendall, MD Assistant Professor Oncologic Sciences University of South Florida Assistant Member, Moffit Cancer Center Department of Malignant Hematology Tampa, Florida

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of these CME activities:

Luke Fletcher, MD 
Consultant: Genzyme, Morphosys, Novartis, Pharmaessentia, Sanofi, Servier
Speaker: CTI Biopharma

Aaron T. Gerds, MD, MS 
Consultant: AbbVie, Bristol Myers Squibb, CTI Biopharma, GSK/Sierra Oncology, Imago, Morphosys, Novartis, PharmaEssentia

Tania Jain, MBBS
Advisory Boards: AbbVie, Blueprint Medicine, Cogent Biosciences, CTI Biopharma, Kite, Protagonist therapeutics, Telios Pharma

Andrew Kyukendall, MD
Consultant: AbbVie, GSK
Honoraria: Bristol Myers Squibb, CTI Biopharma, Incyte, MorphoSys
Research support: Bristol Myers Squibb, Janssen, MorphoSys

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 18, 2023 through January 18, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 6, 2023
Expiration date: April 6, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc.

PROGRAM OVERVIEW

Homozygous familial hypercholesterolemia (HoFH) is a genetic disorder characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-C), leading to premature cardiovascular disease. Affected individuals are typically less responsive or unresponsive to standard lipid-lowering therapies (ie, statins and PCSK9 inhibitors) and may benefit from treatments with alternative mechanisms of action, such as the recently FDA-approved ANGPTL3 inhibitor evinacumab. With this in mind, this program has been designed to educate clinicians about the prevalence of HoFH, the importance of HoFH screening, and the benefits and limitations of current therapies for lipid management in patients with the disease.

TARGET AUDIENCE

This educational activity has been designed for US internal medicine physicians, nurse practitioners, and physician assistants involved in the identification, diagnosis, and management of patients with HoFH.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Apply knowledge of cardinal symptoms and strategies for early identification of HoFH
• Discuss recommendations for cascade screening for HoFH and indications for appropriate referral
• Discuss the role of low-density lipoprotein receptor-independent treatment strategies for patients with HoFH

FACULTY

Robert S. Rosenson, MD, FACC Director, Metabolism and Lipids Unit Mount Sinai Health System Professor of Medicine, Cardiology Zena and Michael A. Weiner Cardiovascular Institute Marie Josee and Henry R. Kravis Center for Cardiovascular Health Mount Sinai Heart, Icahn School of Medicine at Mount Sinai New York, New York

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Robert S. Rosenson, MD, FACC
Consultant: Amgen, Avilar, CRISPER Therapeutics, Eli Lilly, Lipigon, Novartis, New Amsterdam, Novartis, Precision Biosciences, Regeneron, UltraGenyx, Verve Therapeutics
Honoraria: Kowa
Patent Beneficiary: PCT/US2019/026364, PCT/US2020/63104926, PCT/US2021/63248837
Research: Amgen, Arrowhead, Eli Lilly, NIH, Novartis, Regeneron
Stock Holder: Medimergent, LLC

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 6, 2023 through April 6, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 6, 2023
Expiration date: April 6, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc.

PROGRAM OVERVIEW

Homozygous familial hypercholesterolemia (HoFH) is a genetic disorder characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-C), leading to premature cardiovascular disease. Affected individuals are typically less responsive or unresponsive to standard lipid-lowering therapies (ie, statins and PCSK9 inhibitors) and may benefit from treatments with alternative mechanisms of action, such as the recently FDA-approved ANGPTL3 inhibitor evinacumab. With this in mind, this program has been designed to educate clinicians about the prevalence of HoFH, the importance of HoFH screening, and the benefits and limitations of current therapies for lipid management in patients with the disease.

TARGET AUDIENCE

This educational activity has been designed for US cardiologists involved in the identification, diagnosis, and management of patients with HoFH.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Contrast the estimated prevalence versus the number of patients diagnosed with familial hypercholesterolemia (FH)
• Employ cascade screening to ensure case identification in first degree relatives of patients with HoFH
• Utilize currently available therapies for appropriate treatment of patients with HoFH

FACULTY

Mary P. McGowan, MD Assistant Professor of Medicine Geisel School of Medicine at Dartmouth Co-Director, Lipid Clinic Dartmouth Hitchcock Medical Center Lebanon, New Hampshire

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Mary P. McGowan, MD 
Consultant: Novartis
Speaker: Abbott

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 6, 2023 through April 6, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: October 4, 2023
Expiration date: January 4, 2024
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This educational activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by educational grants from AstraZeneca Pharmaceuticals, GSK, and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

Ovarian cancer is a less common type of cancer but one of the deadliest. Diagnoses at a more advanced stage are typical and associated with significantly worse outcomes. Poor outcomes are exacerbated by healthcare disparities associated with ovarian cancer and patient-reported communication challenges.

In this Twitter-based Clinical Brief, experts Martina Murphy, MD, Eleonora Teplinsky, MD, Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC, Gregg Nelson, MD, PhD, FRCSC, and Brian Slomovitz, MD, MS, FACOG  will discuss a succinct clinical case – written by a practicing gynecologic oncologist – with insight and guidance on the emerging role of first line polymerase inhibitors as it relates to ovarian cancer.

TARGET AUDIENCE

This activity is designed to meet the professional educational needs of gynecologic and medical oncologists, as well as other clinicians involved in the treatment and management of patients with ovarian cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Apply current guideline recommendations for genetic testing and treatment to improve the health outcomes of women with EOC

FACULTY CO-CHAIRS

	Martina C. Murphy, MD Associate Professor of Medicine Program Director, Hematology/Oncology Fellowship University of Florida Assistant Director, Clinical Research Education & Professional Development Medical Director, Communication Strategies & Digital Innovation University of Florida Health Cancer Center Gainesville, Florida
	Eleonora Teplinsky, MD Head, Breast Medical Oncology Clinical Assistant Professor of Medicine Icahn School of Medicine at Mount Sinai Paramus, New Jersey
	Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC Clinical Program Director of GYN Oncology Mount Sinai Health System New York, New York

FACULTY DISCUSSANTS

	Gregg Nelson, MD, PhD, FRCSC Professor and Chief of Gynecologic Oncology Department of Obstetrics & Gynecology Cumming School of Medicine University of Calgary Calgary, Alberta
	Brian Slomovitz, MD, MS, FACOG Director, Gynecologic Oncology Co-Chair, Cancer Research Committee Mount Sinai Medical Center Board of Directors and Uterine Cancer Lead GOG Foundation Miami, Florida

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC does not have any financial relationships or relationships to products or devices with ineligible companies.

Martina Murphy, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

Gregg Nelson, MD, PhD, FRCSC does not have any financial relationships or relationships to products or devices with ineligible companies.

Brian Slomovitz, MD
Consultation: Aadi, AstraZeneca, Eisai, Genentech, GOG Foundation, GSK, Immunogen, Incyte, Merck, Novocure, Regeneron, Seagen, Verastem
Fees: Seagen
Research: Incyte, Merck, Novartis

Eleonora Teplinsky, MD
Advisory Board: AstraZeneca
Medical Advisor: FloHealth, Sermo

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of October 4, 2023 through January 4, 2023, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: September 29, 2023
Expiration date: March 29, 2024
Estimated time to complete activity: 30 minutes

PROVIDER STATEMENT

This activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc.

PROGRAM OVERVIEW

Homozygous familial hypercholesterolemia (HoFH) is a genetic disorder characterized by markedly elevated levels of low-density lipoprotein cholesterol (LDL-C), leading to premature cardiovascular disease. Affected individuals are typically less responsive or unresponsive to standard lipid-lowering therapies (ie, statins and PCSK9 inhibitors) and may benefit from treatments with alternative mechanisms of action, such as the recently FDA-approved ANGPTL3 inhibitor evinacumab. With this in mind, this program has been designed to educate clinicians about the prevalence of HoFH, the importance of HoFH screening, and the benefits and limitations of current therapies for lipid management in patients with the disease. The nationally-recognized expert faculty in HoFH presenting this activity will provide practical advice geared for an audience of cardiologists regarding the best strategies to improve patient access to newer lipid-lowering therapies.

TARGET AUDIENCE

This educational activity has been designed for US cardiologists involved in the identification, diagnosis, and management of patients with HoFH.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Contrast the estimated prevalence versus the number of patients diagnosed with familial hypercholesterolemia (FH)
• Apply knowledge of cardinal symptoms and strategies for early identification of HoFH
• Employ cascade screening to ensure case identification in first degree relatives of patients with HoFH
• Discuss the role of low-density lipoprotein receptor-independent treatment strategies for patients with HoFH
• Utilize currently available therapies for appropriate treatment of patients with HoFH

FACULTY

Robert S. Rosenson, MD, FACC Director, Metabolism and Lipids Unit Mount Sinai Health System Professor of Medicine, Cardiology Zena and Michael A. Weiner Cardiovascular Institute, Marie Josee and Henry R. Kravis Center for Cardiovascular Health Mount Sinai Heart, Icahn School of Medicine at Mount Sinai New York, New York

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Robert S. Rosenson, MD, FACC
Consultant: Amgen, Avilar, CRISPER Therapeutics, Eli Lilly, Lipigon, Novartis, New Amsterdam, Novartis, Precision Biosciences, Regeneron, UltraGenyx, Verve Therapeutics
Honoraria: Kowa
Patent Beneficiary: PCT/US2019/026364, PCT/US2020/63104926, PCT/US2021/ 63248837
Research: Amgen, Arrowhead, Eli Lilly, NIH, Novartis, Regeneron
Stock Holder: Medimergent, LLC

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of September 29, 2023 through March 29, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 70% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: September 14, 2023
Expiration date: September 14, 2024
Estimated time to complete activity: 90 minutes

PROVIDER STATEMENT

This program is provided by Integrity Continuing Education, Inc., in partnership with U=U plus, a fiscally sponsored project of Social and Environmental Entrepreneurs, Inc. (SEE).

DISCLOSURE OF COMMERCIAL SUPPORT

This program has been supported by an independent educational grant from Gilead Sciences, Inc.

PROGRAM OVERVIEW

Recent advances in antiretroviral therapy have improved the outlook for people living with human immunodeficiency virus (HIV), allowing them greater freedom to focus on their lives, rather than their diagnosis. When considering prevention and treatment, patients have many options, including single-tablet, once-daily, and long-acting injectable antiretroviral regimens. Most recently, the approval of a novel, long-acting treatment for patients with multidrug-resistant HIV has been added to the treatment armamentarium.

Join our distinguished faculty and patient ambassadors to learn more about advances in HIV prevention and treatment, including holistic approaches to care. Discussion will include strategies to reduce disparities, increasing prevention efforts and patient engagement, and the current and emerging approaches to HIV treatment and prevention.

TARGET AUDIENCE

This educational program is designed for HIV specialists, infectious disease practitioners, advanced nurse practitioners and physician assistants, nurses, and other clinicians who manage PLWH, as well as the patient population of PLWH.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Describe pre-exposure prophylaxis guideline recommendations and implement strategies to identify patients who are eligible for pre-exposure prophylaxis
• Differentiate oral and long-acting injectable antiretroviral regimens and implement strategies to mitigate and manage potential adverse events
• Compare approved and emerging antiretroviral therapies in the context of multidrug-resistant HIV
• Utilize shared decision-making to provide optimal care for patients at risk of acquiring or living with HIV

FACULTY CO-CHAIRS

	Onyema Ogbuagu, MD, MBBCh, FACP, FIDSA Associate Professor of Medicine Section of Infectious Diseases, Yale School of Medicine New Haven, Connecticut
	Sorana Segal Maurer, MD Professor of Clinical Medicine Weill Cornell Medicine Cornell University New York, New York

PATIENT AMBASSADORS

Cameron Kinker
Senior Director, Projects and Operations
U=U, Plus

Bryan-Tyler Orr
Research Fellow
U=U, Plus

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Cameron Kinker does not have any financial relationships or relationships to products or devices with ineligible companies.

Onyema Ogbuagu, MD, MBBCh, FACP, FIDSA
Advisor: Gilead Sciences, Viiv
Speaker: Gilead Sciences

Bryan-Tyler Orr does not have any financial relationships or relationships to products or devices with ineligible companies.

Sorana Segal-Maurer, MD
Advisor: Gilead Sciences, Janssen Therapeutics, Theratechnologies Inc., ViiV
Consultant: Gilead Sciences, Janssen Therapeutics, Theratechnologies Inc., ViiV
Speaker: Gilead Sciences

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of September 14, 2023 through September 14, 2024 participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 66% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: September 13, 2023
Expiration date: December 13, 2023
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This educational activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by educational grants from AstraZeneca Pharmaceuticals, GSK, and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

Ovarian cancer is a less common type of cancer but one of the deadliest. Diagnoses at a more advanced stage are typical and associated with significantly worse outcomes. Poor outcomes are exacerbated by healthcare disparities associated with ovarian cancer and patient-reported communication challenges.

In this Twitter-based Clinical Brief, experts Martina Murphy, MD, Eleonora Teplinsky, MD, Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC, Katherine Fuh, MD, PhD, and Brian Slomovitz, MD, MS, FACOG will discuss a succinct clinical case – written by a practicing gynecologic oncologist – with insight and guidance on selecting treatment as it relates to platinum-resistant ovarian cancer.

TARGET AUDIENCE

This activity is designed to meet the professional educational needs of gynecologic and medical oncologists, as well as other clinicians involved in the treatment and management of patients with ovarian cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Apply current guideline recommendations for genetic testing and treatment to improve the health outcomes of women with epithelial ovarian cancer

FACULTY CO-CHAIRS

	Martina C. Murphy, MD Associate Professor of Medicine Program Director, Hematology/Oncology Fellowship University of Florida Assistant Director, Clinical Research Education & Professional Development Medical Director, Communication Strategies & Digital Innovation University of Florida Health Cancer Center Gainesville, Florida
	Eleonora Teplinsky, MD Head, Breast Medical Oncology Clinical Assistant Professor of Medicine Icahn School of Medicine at Mount Sinai Paramus, New Jersey
	Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC Clinical Program Director of GYN Oncology Mount Sinai Health System New York, New York

FACULTY DISCUSSANTS

	Katherine Fuh, MD, PhD Associate Professor, Division of Gynecologic Oncology Director of Basic and Translational Research in Gynecologic Oncology Department of Obstetrics and Gynecology University of California, San Franscisco San Franscisco, California
	Brian Slomovitz, MD, MS, FACOG Director, Gynecologic Oncology Co-Chair, Cancer Research Committee Mount Sinai Medical Center Board of Directors and Uterine Cancer Lead GOG Foundation Miami, Florida

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC does not have any financial relationships or relationships to products or devices with ineligible companies.

Katherine Fuh, MD
Advisor: Aravive, GSK, Immunogen, Mersana

Martina Murphy, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

Brian Slomovitz, MD
Consultation: Aadi, AstraZeneca, Eisai, Genentech, GOG Foundation, GSK, Immunogen, Incyte, Merck, Novocure, Regeneron, Seagen, Verastem
Fees: Seagen
Research: Incyte, Merck, Novartis

Eleonora Teplinsky, MD
Advisory Board: AstraZeneca
Medical Advisor: FloHealth, Sermo

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of September 13, 2023 through December 13, 2023, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: August 30, 2023
Expiration date: November 30, 2023
Estimated time to complete activity: 15 minutes

PROVIDER STATEMENT

This educational activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by educational grants from AstraZeneca Pharmaceuticals, GSK, and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

Ovarian cancer is a less common type of cancer but one of the deadliest. Diagnoses at a more advanced stage are typical and associated with significantly worse outcomes. Poor outcomes are exacerbated by healthcare disparities associated with ovarian cancer and patient-reported communication challenges.

In this Twitter-based Clinical Brief, experts Martina Murphy, MD, Eleonora Teplinsky, MD, Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC, Lindsey McAlarnen, MD, FACOG, and Gregg Nelson, MD, PhD, FRCSC will discuss a succinct clinical case – written by a practicing gynecologic oncologist – with insight and guidance on appropriate testing, selecting treatment, and assessing adverse events (AEs) as they relate to first-line poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance therapy.

TARGET AUDIENCE

This activity is designed to meet the professional educational needs of gynecologic and medical oncologists, as well as other clinicians involved in the treatment and management of patients with ovarian cancer.

LEARNING OBJECTIVE

Upon completion of this educational activity, participants should be able to:

• Identify key clinical trial information that can be utilized in the treatment decision-making process (endpoints, patient population, outcomes, AE profile, etc)

FACULTY CO-CHAIRS

	Martina C. Murphy, MD Associate Professor of Medicine Program Director, Hematology/Oncology Fellowship University of Florida Assistant Director, Clinical Research Education & Professional Development Medical Director, Communication Strategies & Digital Innovation University of Florida Health Cancer Center Gainesville, Florida
	Eleonora Teplinsky, MD Head, Breast Medical Oncology Clinical Assistant Professor of Medicine Icahn School of Medicine at Mount Sinai Paramus, New Jersey
	Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC Clinical Program Director of GYN Oncology Mount Sinai Health System New York, New York

FACULTY DISCUSSANTS

	Lindsey McAlarnen, MD, FACOG Assistant Professor Division of Gynecological Oncology Department of Obstetrics and Gynecology University of Nebraska Medical Center Omaha, Nebraska
	Gregg Nelson, MD, PhD, FRCSC Professor and Chief of Gynecologic Oncology Department of Obstetrics & Gynecology Cumming School of Medicine University of Calgary Calgary, Alberta

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC does not have any financial relationships or relationships to products or devices with ineligible companies.

Lindsey McAlarnen, MD, FACOG does not have any financial relationships or relationships to products or devices with ineligible companies.

Martina Murphy, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

Gregg Nelson, MD, PhD, FRCSC does not have any financial relationships or relationships to products or devices with ineligible companies.

Eleonora Teplinsky, MD
Advisory Board: Astra Zeneca
Medical Advisor: FloHealth, Sermo

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of August 30, 2023 through November 30, 2023, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 100% and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.

Release date: August 31, 2023
Expiration date: August 31, 2024
Estimated time to complete activity: 45 minutes

PROVIDER STATEMENT

This educational activity is provided by Integrity Continuing Education, Inc.

DISCLOSURE OF COMMERCIAL SUPPORT

This educational activity is supported by educational grants from AstraZeneca Pharmaceuticals, GSK, and Merck Sharp & Dohme LLC.

PROGRAM OVERVIEW

Ovarian cancer is a less common type of cancer but one of the deadliest. Diagnoses at a more advanced stage are typical and associated with significantly worse outcomes. Poor outcomes are exacerbated by healthcare disparities associated with ovarian cancer and patient-reported communication challenges.

A series of three succinct clinical cases – written by a practicing gynecologic oncologist – will allow you to choose appropriate testing, select treatment, and assess adverse events, with insight and guidance on decisions and management provided by expert faculty after each case.

Join OC experts Martina Murphy, MD, Eleonora Teplinksy, MD, and Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC as they address the ongoing disparities in care, strategies to improve communication between patients and their healthcare team, and patient management.

TARGET AUDIENCE

This activity is designed to meet the professional educational needs of gynecologic and medical oncologists, as well as other clinicians involved in the treatment and management of patients with ovarian cancer.

LEARNING OBJECTIVES

Upon completion of this educational activity, participants should be able to:

• Apply current guideline recommendations for genetic testing and treatment to improve the health outcomes of women with epithelial ovarian cancer
• Identify key clinical trial information that can be utilized in the treatment decision-making process (endpoints, patient population, outcomes, adverse event profile, etc)
• Identify tools to improve clinician-patient communication and the care of women with epithelial ovarian cancer.

FACULTY CO-CHAIRS

	Martina C. Murphy, MD Associate Professor of Medicine Program Director, Hematology/Oncology Fellowship University of Florida Assistant Director, Clinical Research Education & Professional Development Medical Director, Communication Strategies & Digital Innovation University of Florida Health Cancer Center Gainesville, Florida
	Eleonora Teplinsky, MD Head, Breast Medical Oncology Clinical Assistant Professor of Medicine Icahn School of Medicine at Mount Sinai Paramus, New Jersey
	Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC Clinical Program Director of GYN Oncology Mount Sinai Health System New York, New York

CLINICAL CASE DEVELOPMENT FACULTY

Megan Hutchcraft, MD Gynecologic Oncologist Carle Cancer Institute Assistant Clinical Professor Carle Illinois College of Medicine University of Illinois at Urbana-Champaign Champaign, Illinois

DISCLOSURE OF CONFLICTS OF INTEREST

Integrity Continuing Education, Inc. requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose any financial relationships with ineligible companies. All identified relevant financial relationships are thoroughly vetted by Integrity Continuing Education, Inc. for fair balance, scientific objectivity of studies mentioned in the materials or used as the basis for content, and appropriateness of patient care recommendations. All relevant financial relationships have been mitigated.

The following faculty/planners reported the financial relationships or relationships to products or devices they have with ineligible companies related to the content of this CME activity:

Mollie Finkel, RN, MSN, WHNP-BC, AOCNP-BC, does not have any financial relationships or relationships to products or devices with ineligible companies.

Megan Hutchcraft, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

Martina Murphy, MD does not have any financial relationships or relationships to products or devices with ineligible companies.

Eleonora Teplinsky, MD
Advisory Board: Astra Zeneca
Medical Advisor: FloHealth, Sermo

The Integrity Continuing Education, Inc. planners and managers do not have any financial relationships or relationships to products or devices with ineligible companies.

DIRECTIONS TO LEARNER

There are no fees for participating and receiving CME credit for this activity. During the period of August 31, 2023 through August 31, 2024, participants must:

• Read the learning objectives
• Complete the pretest
• Study the educational activity
• Complete the posttest and the evaluation form

A statement of credit will be issued only upon receipt of a completed posttest with a score of 66% or better and a completed activity evaluation form.

ACCREDITATION STATEMENT

Integrity Continuing Education, Inc. is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION

Integrity Continuing Education, Inc. designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit^TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CONTACT INFORMATION

For information about ACCME accreditation of this activity, please contact Integrity Continuing Education, Inc. at (855) 835-4004 or cme@integrityce.com.

DISCLOSURE OF UNLABELED USE

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Integrity Continuing Education, Inc. does not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of any organization associated with this activity. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

MEDIA

Internet

PRIVACY POLICY

When you participate in an online educational activity sponsored by Integrity Continuing Education, Inc., you will be asked for your name, degree(s), affiliation(s), street address, telephone number and…(continued)

MINIMUM SYSTEM REQUIREMENTS

Minimum Processor: Intel Pentium 4, 2.33 + GHz (or equivalent)
Operating Systems: Windows XP, Windows 2000, Windows Vista, Windows 7, Windows 10, and Mac OS
Plug-in: Adobe^® Flash^® Player 10

• Adobe^® Flash^® Player 10 plug-in should be downloaded
• Click on the “Agree and install now” button after unchecking the optional McAfee Security Scan Plus

For optimal performance, the use of Internet Explorer below 8 is not recommended

For a full listing of recommended operating systems, browsers, and system configurations, please click on the link below:
Click here for more information on minimum system requirements

DISCLAIMER

The information provided at this activity is for continuing education purposes only and is not meant to substitute for the independent medical judgment of a physician relative to diagnostic and treatment options of a specific patient’s medical condition.